PMID- 9449661
OWN - NLM
STAT- MEDLINE
DCOM- 19980218
LR  - 20071114
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 139
IP  - 2
DP  - 1998 Feb
TI  - Normal sexual function in male mice lacking a functional type I interleukin-1 
      (IL-1) receptor.
PG  - 815-8
AB  - Previous studies have shown that macrophages and their cytokine products, 
      particularly interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF alpha), 
      regulate testicular Leydig cell steroidogenesis in vitro and in vivo. However, 
      the data concerning IL-1 have been somewhat contradictory, showing both 
      inhibitory and stimulatory effects of IL-1 depending on the experimental 
      conditions. In the present studies, mice lacking a functional type I IL-1 
      receptor (IL-1R]; the only IL-1 receptor subtype capable of IL-1-induced signal 
      transduction) were used to examine the role of this cytokine in vivo. The data 
      show that the absence of IL-1 signal transduction has no effect on steroidogenic 
      enzyme concentrations within the Leydig cells, and the males have normal serum 
      testosterone concentrations. Moreover, epididymal sperm numbers are normal in 
      IL-1RI nullizygous males in contrast to recent reports of a role for IL-1 in germ 
      cell proliferation and DNA synthesis. Taken together these observations suggest 
      that IL-1 signalling is not essential for Leydig cell function or spermatogenesis 
      in vivo and highlight the need to reassess many of the current methods of 
      experimental approaches for examining cytokine function in vitro.
FAU - Cohen, P E
AU  - Cohen PE
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, New York 10461, USA.
FAU - Pollard, J W
AU  - Pollard JW
LA  - eng
GR  - HD30280/HD/NICHD NIH HHS/United States
GR  - P30-CA1330/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Receptors, Interleukin-1)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Epididymis/cytology
MH  - *Gene Deletion
MH  - Male
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Receptors, Interleukin-1/*genetics
MH  - Reference Values
MH  - Reproduction/physiology
MH  - Sexual Behavior, Animal/*physiology
MH  - Sperm Count
MH  - Testis/enzymology
EDAT- 1998/02/04 00:00
MHDA- 1998/02/04 00:01
CRDT- 1998/02/04 00:00
PHST- 1998/02/04 00:00 [pubmed]
PHST- 1998/02/04 00:01 [medline]
PHST- 1998/02/04 00:00 [entrez]
AID - 10.1210/endo.139.2.5914 [doi]
PST - ppublish
SO  - Endocrinology. 1998 Feb;139(2):815-8. doi: 10.1210/endo.139.2.5914.