PMID- 9450230
OWN - NLM
STAT- MEDLINE
DCOM- 19980304
LR  - 20180215
IS  - 0300-5526 (Print)
IS  - 0300-5526 (Linking)
VI  - 40
IP  - 2-3
DP  - 1997
TI  - Human T cell lymphotropic retroviruses: association with diseases of the nervous 
      system.
PG  - 132-42
AB  - In less than 1% of persistently infected individuals, human T cell lymphotropic 
      virus type I (HTLV-I) causes a chronic inflammatory disease of the central 
      nervous system (CNS), called HTLV-I-associated myelopathy/tropical spastic 
      paraparesis. Important prerequisites for disease induction are oligoclonal 
      expansion of HTLV-I-infected CD4+ T lymphocytes, their trafficking across the 
      blood-brain barrier, expression of viral proteins in the CNS, and an increased 
      immune response within the CNS. The HTLV-I Tax1 protein has unique abilities to 
      transactivate viral and cellular genes in T lymphocytes, but possibly also in 
      cells of the CNS. Thus Tax1 supports the persistence of HTLV-I, the ongoing 
      immune responses within the CNS and the destruction of myelin and axons, most 
      pronounced in the thoracic spinal cord.
FAU - Kitze, B
AU  - Kitze B
AD  - Department of Neurology, Gottingen University, Germany. bkitze@compuserve.com
FAU - Brady, J N
AU  - Brady JN
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Intervirology
JT  - Intervirology
JID - 0364265
SB  - IM
MH  - Animals
MH  - Genetic Variation
MH  - Genome, Viral
MH  - *Human T-lymphotropic virus 1/genetics/immunology/isolation & purification
MH  - Humans
MH  - *Paraparesis, Tropical Spastic/immunology/pathology/virology
EDAT- 1997/01/01 00:00
MHDA- 1998/02/05 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/02/05 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1159/000150540 [doi]
PST - ppublish
SO  - Intervirology. 1997;40(2-3):132-42. doi: 10.1159/000150540.