PMID- 9452725
OWN - NLM
STAT- MEDLINE
DCOM- 19980209
LR  - 20161209
IS  - 0755-4982 (Print)
IS  - 0755-4982 (Linking)
VI  - 26
IP  - 34
DP  - 1997 Nov 8
TI  - [Thymic and bronchial neuroendocrine tumors in multiple endocrine neoplasia type 
      1. GENEM1].
PG  - 1616-21
AB  - OBJECTIVES: Multiple endocrine neoplasia type 1 (MEN 1) mainly affects 
      parathyroid glands, pancreatic islets and pituitary gland. The aim of this study 
      in 95 MEN 1 patients was to examine less frequent localizations thymic and 
      bronchic neuroendocrine tumors (NET). PATIENTS AND METHODS: Two cases of bronchic 
      NET were observed, both in women, and 4 cases of thymic NET, all in men, giving a 
      prevalence of 7.3%. These NET were often asymptomatic. A metastatic diffusion was 
      observed in 3 cases. Elevated plasma levels of glycoprotein hormone alpha subunit 
      (SU) and FSH were observed in 3 and 1 cases respectively. Immunohistochemistry 
      indicated the tumor cells to be frequently positively stained for HCG alpha and 
      FSH. DISCUSSION: We conclude that all patients with MEN 1 should undergo 
      screening for thoracic NET, especially in high risk familial subgroups and in 
      case of elevated plasma alpha SU or FSH.
FAU - Murat, A
AU  - Murat A
AD  - Clinique d'Endocrinologie, Hotel-Dieu, Nantes.
FAU - Heymann, M F
AU  - Heymann MF
FAU - Bernat, S
AU  - Bernat S
FAU - Dupas, B
AU  - Dupas B
FAU - Delajartre, A Y
AU  - Delajartre AY
FAU - Calender, A
AU  - Calender A
FAU - Despins, P
AU  - Despins P
FAU - Michaud, J L
AU  - Michaud JL
FAU - Giraud, S
AU  - Giraud S
FAU - Le Bodic, M F
AU  - Le Bodic MF
FAU - Charbonnel, B
AU  - Charbonnel B
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Tumeurs neuro-endocrines thymiques et bronchiques au cours des neoplasies 
      endocrines multiples de type 1. GENEM1.
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Adult
MH  - Bronchial Neoplasms/diagnosis/immunology/*physiopathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/immunology/*physiopathology
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Thymus Neoplasms/diagnosis/immunology/*physiopathology
EDAT- 1998/02/07 00:00
MHDA- 1998/02/07 00:01
CRDT- 1998/02/07 00:00
PHST- 1998/02/07 00:00 [pubmed]
PHST- 1998/02/07 00:01 [medline]
PHST- 1998/02/07 00:00 [entrez]
PST - ppublish
SO  - Presse Med. 1997 Nov 8;26(34):1616-21.