PMID- 9452788
OWN - NLM
STAT- MEDLINE
DCOM- 19980211
LR  - 20191024
IS  - 0753-3322 (Print)
IS  - 0753-3322 (Linking)
VI  - 51
IP  - 9
DP  - 1997
TI  - Neutrophil function and glutathione-peroxidase (GSH-px) activity in healthy 
      individuals after treatment with N-acetyl-L-cysteine.
PG  - 388-90
AB  - The objective of this study was to evaluate the effect of N-acetyl-L-cysteine 
      (NAC) on neutrophilic functions and as an antioxidant. NAC, 600 mg daily, given 
      orally to healthy individuals for a period of 2 weeks, affected some functions of 
      human neutrophilic granulocytes when tested in vitro. NAC treatment caused a 
      decrease in the production of superoxide anions by stimulated neutrophils and the 
      improvement of their phagocytic capacity although it did not affect their random 
      or chemotactic migration. The level of glutathione peroxidase (GSH-px) in 
      thrombocytes of the NAC-treated individuals was increased in comparison with the 
      activity before treatment. These results suggest that NAC might act as a 
      scavenger of oxygen-derived free radicals released by stimulated neutrophils and 
      thereby protect the tissue against the radical caused injury as well as optimize 
      phagocytosis.
FAU - Urban, T
AU  - Urban T
AD  - Apoteksbolaget AB, Huddinge Hospital, Sweden.
FAU - Akerlund, B
AU  - Akerlund B
FAU - Jarstrand, C
AU  - Jarstrand C
FAU - Lindeke, B
AU  - Lindeke B
LA  - eng
PT  - Journal Article
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Free Radical Scavengers)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/administration & dosage/*pharmacology
MH  - Adult
MH  - Analysis of Variance
MH  - Free Radical Scavengers/administration & dosage/*pharmacology
MH  - Glutathione Peroxidase/*metabolism
MH  - Healthy Worker Effect
MH  - Humans
MH  - Middle Aged
MH  - Neutrophils/*physiology
MH  - Phagocytosis/drug effects
MH  - Volunteers
EDAT- 1997/01/01 00:00
MHDA- 1998/02/07 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/02/07 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S0753332297894310 [pii]
AID - 10.1016/s0753-3322(97)89431-0 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 1997;51(9):388-90. doi: 10.1016/s0753-3322(97)89431-0.