PMID- 9453123
OWN - NLM
STAT- MEDLINE
DCOM- 19980226
LR  - 20190831
IS  - 0378-1135 (Print)
IS  - 0378-1135 (Linking)
VI  - 58
IP  - 2-4
DP  - 1997 Nov
TI  - Homologous challenge of porcine reproductive and respiratory syndrome virus 
      immunity in pregnant swine.
PG  - 113-25
AB  - The clinical consequences of single or multiple exposure of pregnant gilts to 
      porcine reproductive and respiratory syndrome virus (PRRSV) at various stages of 
      gestation were determined. Thirty-three pregnant gilts were allotted to 6 
      experimental groups (5 to 7 gilts/group). Gilts of groups 1 to 5 were exposed to 
      strain NADC-8 of PRRSV at the following times: group 1, gestation day (GD) 1; 
      group 2, GDs 1 and 90; group 3, GD 30; group 4, GDs 30 and 90; group 5, GD 90. 
      Virus exposure was by either intrauterine (GD 1) or oronasal (GDs 30 and 90) 
      inoculation. Gilts of group 6 were kept as nonexposed controls. Gilts were either 
      necropsied on or about GD 111 (groups 1 to 5) or were allowed to farrow (group 
      6). The detection of PRRSV in serum of fetuses and piglets (within 12 hof birth) 
      was considered evidence of transplacental infection. Transplacental infection and 
      virus-induced death were and were not confirmed for groups 3, 4, and 5 and for 
      groups 1, 2, and 6, respectively. Collectively, the results indicated that 
      intrauterine exposure to PRRSV at GD 1 was without clinical effect (groups 1 and 
      2) and provided protection against subsequent exposure to the same strain of 
      virus at GD 90 (group 2). The highest incidence of transplacental infection and 
      fetal death followed a single exposure to PRRSV at GD 90 (group 5).
FAU - Lager, K M
AU  - Lager KM
AD  - Virology Swine Research Unit, National Animal Disease Center, USDA, Ames, IA 
      50010, USA. klager@nadc.ars.usda.gov
FAU - Mengeling, W L
AU  - Mengeling WL
FAU - Brockmeier, S L
AU  - Brockmeier SL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
SB  - IM
MH  - Animals
MH  - Female
MH  - Fetus
MH  - Gestational Age
MH  - Infectious Disease Transmission, Vertical/*veterinary
MH  - Lymph Nodes/virology
MH  - Macrophages, Peritoneal/virology
MH  - Palatine Tonsil/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/isolation & 
      purification
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/immunology/*veterinary/virology
MH  - Pregnancy, Animal/*immunology
MH  - Swine
MH  - Time Factors
MH  - Uterus
EDAT- 1998/02/07 00:00
MHDA- 1998/02/07 00:01
CRDT- 1998/02/07 00:00
PHST- 1998/02/07 00:00 [pubmed]
PHST- 1998/02/07 00:01 [medline]
PHST- 1998/02/07 00:00 [entrez]
AID - S0378-1135(97)00160-0 [pii]
AID - 10.1016/s0378-1135(97)00160-0 [doi]
PST - ppublish
SO  - Vet Microbiol. 1997 Nov;58(2-4):113-25. doi: 10.1016/s0378-1135(97)00160-0.