PMID- 9453828
OWN - NLM
STAT- MEDLINE
DCOM- 19980205
LR  - 20061115
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 181
IP  - 6
DP  - 1997 Jun-Jul
TI  - [The discovery of three novel human viruses, human herpesviruses 6, 7, and 8].
PG  - 1009-22
AB  - Three novel human herpesviruses have been discovered in the last years: human 
      herpesvirus 6 (HHV-6) in 1986, human herpesvirus 7 (HHV-7) in 1990, human 
      herpesvirus 8 (HHV-8) in 1994. HHV-6 and HHV-7 were identified after their 
      isolation from blood lymphocyte cultures, while HHV-8 was first detected by means 
      of a specific molecular biology approach in the search for the etiologic agent of 
      Kaposi's sarcoma. The three viruses infect lymphocytes, T-cells in the case of 
      HHV-6 and HHV-7, B-cells in the case of HHV-8. Human infection with HHV-6 and 
      HHV-7 is ubiquitous and widespread while HHV-8 infection seems to be more 
      restricted, at least in Western countries. The propagation in cell culture in 
      vitro can be done easily with HHV-6, with more difficulties in the case of HHV-7 
      and has not been completely obtained in the case of HHV-8. The polymerase chain 
      reaction is the common method for the detection of these three viruses in human 
      samples. The oncogenic role of HHV-6 and HHV-7 which were both classified in 
      Betaherpesvirinae subfamily has not been convincingly demonstrated. HHV-8, 
      classified as a member of Gammaherpesvirinae subfamily, is strongly associated 
      with three lymphoproliferative diseases: Kaposi's sarcoma, Castleman's disease 
      and primary effusion lymphomas.
FAU - Agut, H
AU  - Agut H
AD  - Laboratoire de Virologie, CERVI, Groupe Hospitalier Pitie-Salpetriere, Paris. 
      henri.agut@psl.ap-hop-paris.fr
FAU - Calvez, V
AU  - Calvez V
FAU - Fillet, A M
AU  - Fillet AM
FAU - Huraux, J M
AU  - Huraux JM
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - La decouverte de trois nouveaux virus humains, les herpesvirus humains 6, 7 et 8.
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
SB  - IM
MH  - Herpesviridae Infections/diagnosis/epidemiology/therapy
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Herpesvirus 7, Human/*isolation & purification
MH  - Herpesvirus 8, Human/*isolation & purification
MH  - Humans
RF  - 50
EDAT- 1997/06/01 00:00
MHDA- 1998/02/07 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1998/02/07 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
PST - ppublish
SO  - Bull Acad Natl Med. 1997 Jun-Jul;181(6):1009-22.