PMID- 9454361
OWN - NLM
STAT- MEDLINE
DCOM- 19980204
LR  - 20080212
IS  - 0040-5930 (Print)
IS  - 0040-5930 (Linking)
VI  - 54
IP  - 11
DP  - 1997 Nov
TI  - [Gastroesophageal reflux].
PG  - 611-6
AB  - Gastroesophageal reflux disease (GERD) is a common, typically chronic recurring 
      disorder. The majority of patients with heartburn and regurgitation have 
      intermittent symptoms for which they do not consult their physicians. The main 
      long-term risk of esophagitis is adenocarcinoma arising from Barrett's 
      metaplasia. There are two principle therapeutic strategies in the treatment of 
      GERD. The use of prokinetic drugs aims at treating the primary motility disorder 
      leading to reflux, whereas acid-suppressive therapy targets at the reduction of 
      gastric acid production to prevent symptoms and complication of GERD. The 
      cornerstone in the treatment of GERD are proton pump inhibitors (PPI). Patients 
      with mild symptoms and rarely relapsing disease may be best treated 
      intermittently. Longterm maintenance acid-suppressive therapy with PPIs is 
      necessary in GERD patients with immediate and severe relapse. At present, 
      eradication of Helicobacter pylori in GERD patients is not recommended. 
      Antireflux surgery is an effective treatment to control gastroesophageal reflux. 
      However, surgery is associated with a low, but still substantial morbidity, a low 
      mortality of up to 0.5% and is only indicated in patients with pharmacological 
      refractory reflux disease.
FAU - Schwizer, W
AU  - Schwizer W
AD  - Departement Innere Medizin, Abteilung Gastroenterologie, Universitatsspital 
      Zurich.
FAU - Fried, M
AU  - Fried M
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Gastroosophageale Refluxkrankheit.
PL  - Switzerland
TA  - Ther Umsch
JT  - Therapeutische Umschau. Revue therapeutique
JID - 0407224
RN  - 0 (Anti-Ulcer Agents)
SB  - IM
MH  - Anti-Ulcer Agents/adverse effects/*therapeutic use
MH  - Combined Modality Therapy
MH  - Esophagitis, Peptic/*drug therapy/etiology
MH  - Fundoplication
MH  - Gastric Emptying/*drug effects
MH  - Gastroesophageal Reflux/*drug therapy/etiology
MH  - Humans
RF  - 26
EDAT- 1998/02/07 00:00
MHDA- 1998/02/07 00:01
CRDT- 1998/02/07 00:00
PHST- 1998/02/07 00:00 [pubmed]
PHST- 1998/02/07 00:01 [medline]
PHST- 1998/02/07 00:00 [entrez]
PST - ppublish
SO  - Ther Umsch. 1997 Nov;54(11):611-6.