PMID- 9454932 OWN - NLM STAT- MEDLINE DCOM- 19980323 LR - 20151119 IS - 0005-2086 (Print) IS - 0005-2086 (Linking) VI - 41 IP - 4 DP - 1997 Oct-Dec TI - Moniliformin from Fusarium fujikuroi culture material and deoxynivalenol from naturally contaminated wheat incorporated into diets of broiler chicks. PG - 957-63 AB - The effects of feeding diets containing 100 mg moniliformin (M)/kg of feed from culture material and 16 mg deoxynivalenol (DON)/kg of feed from naturally contaminated wheat were evaluated in growing broiler chicks from 1 day to 21 days of age. Body weight (BW), body-weight gain, and feed consumption were decreased by feeding M and M plus DON diets. Relative heart weight was increased by the M diet, whereas relative weights of proventriculus, gizzard, and heart were increased by the M plus DON diet. The M diet increased alanine transferase and aspartate transaminase activities and creatinine concentration and decreased mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration (MCHC). The M and DON diet decreased glucose, hemoglobin, and MCHC. Histopathological lesions from the M diet were limited to the kidney and consisted of extensive renal tubular epithelial degeneration plus luminal mineralization. A moderation of the severity of lesions was seen in the tissues of the M plus DON-fed chicks, consisting of generally mild tubular epithelial degeneration. None of the parameters measured were affected by the DON diet. Results indicate additive or less-than-additive toxicity for most parameters when chicks were fed diets containing 100 mg M plus 16 mg DON/kg of feed. Although the concentration of M in this study was high compared with that reported for feedstuffs, additional information on the occurrence and toxicity of M will need to be collected in order to assess the importance of M to the poultry industry. FAU - Harvey, R B AU - Harvey RB AD - United States Department of Agriculture, Agricultural Research Service, Food Animal Protection Research Laboratory, College Station, TX 77845, USA. FAU - Kubena, L F AU - Kubena LF FAU - Rottinghaus, G E AU - Rottinghaus GE FAU - Turk, J R AU - Turk JR FAU - Casper, H H AU - Casper HH FAU - Buckley, S A AU - Buckley SA LA - eng PT - Journal Article PL - United States TA - Avian Dis JT - Avian diseases JID - 0370617 RN - 0 (Cyclobutanes) RN - 0 (Hemoglobins) RN - 0 (Trichothecenes) RN - 31876-38-7 (moniliformin) RN - EC 2.6.1.1 (Aspartate Aminotransferases) RN - EC 2.6.1.2 (Alanine Transaminase) RN - JT37HYP23V (deoxynivalenol) SB - IM MH - Alanine Transaminase/blood MH - Analysis of Variance MH - Animals MH - Aspartate Aminotransferases/blood MH - Body Weight/physiology MH - Chickens/blood/*growth & development/physiology MH - Cyclobutanes/*analysis MH - Diet/*veterinary MH - Eating/physiology MH - Erythrocyte Count MH - Fusarium/*chemistry MH - Heart/anatomy & histology MH - Hemoglobins/analysis MH - Kidney Tubules/cytology MH - Male MH - Organ Size MH - Time Factors MH - Trichothecenes/*analysis MH - Triticum/*chemistry MH - Weight Gain/physiology EDAT- 1998/02/10 00:00 MHDA- 1998/02/10 00:01 CRDT- 1998/02/10 00:00 PHST- 1998/02/10 00:00 [pubmed] PHST- 1998/02/10 00:01 [medline] PHST- 1998/02/10 00:00 [entrez] PST - ppublish SO - Avian Dis. 1997 Oct-Dec;41(4):957-63.