PMID- 9455521
OWN - NLM
STAT- MEDLINE
DCOM- 19980305
LR  - 20190512
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 26
IP  - 1
DP  - 1998 Jan
TI  - Persistence of human herpesvirus 6 according to site and variant: possible 
      greater neurotropism of variant A.
PG  - 132-7
AB  - Little is known of the persistence and pathogenicity of human herpesvirus 6 
      (HHV-6) after primary infection, including the role of strain variant. Over 2 to 
      5 years, 2,716 children and 149 families were studied. Peripheral blood 
      mononuclear cell (PBMC), saliva, and cerebrospinal fluid (CSF) specimens were 
      examined for HHV-6 DNA and variant. Ninety-nine percent of isolates causing 
      primary infection were HHV-6 variant B (HHV-6B), which predominated in 95%-98% of 
      the variants persisting in PBMC and saliva specimens from children and adults. Of 
      668 CSF samples, 13% contained HHV-6 DNA; of 77 children examined after primary 
      infection, 61% had HHV-6 DNA detected only in their CSF and 39% had HHV-6 DNA in 
      both CSF and PBMCs. HHV-6 variant A (HHV-6A) was detected significantly (P = 
      .0001) more frequently in CSF than in PBMCs or saliva. In children for whom HHV-6 
      was identified in both CSF and PBMCs, PBMCs contained only HHV-6B, while CSF 
      contained HHV-6A or HHV-6B, not both. Thus, in patients with dual infection, only 
      HHV-6A persisted in CSF, which suggests that HHV-6A has greater neurotropism. 
      Findings for adults indicate that dual infection occurs; variant persistence is 
      similar to that for children. The frequency of HHV-6A infection increased little 
      with age, thereby indicating that HHV-6A infection remains uncommon into 
      adulthood. This study suggests that HHV-6 variants have different immunobiologic 
      courses and neurotropism.
FAU - Hall, C B
AU  - Hall CB
AD  - Department of Pediatrics, University of Rochester School of Medicine and 
      Dentistry, New York 14642, USA.
FAU - Caserta, M T
AU  - Caserta MT
FAU - Schnabel, K C
AU  - Schnabel KC
FAU - Long, C
AU  - Long C
FAU - Epstein, L G
AU  - Epstein LG
FAU - Insel, R A
AU  - Insel RA
FAU - Dewhurst, S
AU  - Dewhurst S
LA  - eng
GR  - KO4 A 101240/PHS HHS/United States
GR  - R01 A 133020-02/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Brain/*virology
MH  - Child, Preschool
MH  - DNA, Viral/analysis
MH  - Herpesviridae Infections/*virology
MH  - Herpesvirus 6, Human/*classification/isolation & purification
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Leukocytes, Mononuclear/virology
MH  - Saliva/virology
EDAT- 1998/02/10 00:00
MHDA- 1998/02/10 00:01
CRDT- 1998/02/10 00:00
PHST- 1998/02/10 00:00 [pubmed]
PHST- 1998/02/10 00:01 [medline]
PHST- 1998/02/10 00:00 [entrez]
AID - 10.1086/516280 [doi]
PST - ppublish
SO  - Clin Infect Dis. 1998 Jan;26(1):132-7. doi: 10.1086/516280.