PMID- 9456468
OWN - NLM
STAT- MEDLINE
DCOM- 19980423
LR  - 20190512
IS  - 0161-8105 (Print)
IS  - 0161-8105 (Linking)
VI  - 20
IP  - 11
DP  - 1997 Nov
TI  - Familial aspects of narcolepsy-cataplexy in the Czech Republic.
PG  - 1021-6
AB  - A group of 153 probands with narcolepsy included 38 subjects (24.8%) with a 
      familial incidence of excessive daytime sleepiness (EDS). In 15 cases (9.8%), at 
      least one additional family member suffered from narcolepsy-cataplexy; only EDS 
      was present in the remaining 23 cases (15.0%). One thousand eighty-two relatives 
      were evaluated. The percentage of first degree relatives affected with 
      narcolepsy-cataplexy was 2.28% (1.20% if only clinically confirmed cases were 
      accounted); the adequate value for second degree relatives was 1.49%. The 
      occurrence of EDS exceeded these values several times (4.28% in first degree 
      relatives, 6.57% in second degree relatives). The vertical mode of transmission 
      was found in most families. Human leukocyte antigen (HLA) typing was performed in 
      six families with multiple-case incidence of narcolepsy. Forty-one blood samples 
      were analyzed (12 patients with narcolepsy, 7 with only EDS, 2 with sleep apnea 
      syndrome, and 20 healthy relatives). HLA DR2+ and DQB1*0602+ were found in only 8 
      out of 12 narcoleptic patients with cataplexy and in six out of seven patients 
      with isolated attacks of sleepiness. These findings support the hypothesis that 
      there is a common genetic basis for narcolepsy associated with cataplexy and 
      "monosymptomatic" forms of narcolepsy and suggest the existence of non-major 
      histocompatibility complex (MHC) susceptibility factors for narcolepsy.
FAU - Nevsimalova, S
AU  - Nevsimalova S
AD  - Department of Neurology 1st Medical Faculty, Charles University, Prague, Czech 
      Republic.
FAU - Mignot, E
AU  - Mignot E
FAU - Sonka, K
AU  - Sonka K
FAU - Arrigoni, J L
AU  - Arrigoni JL
LA  - eng
GR  - NS 23724/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cataplexy/etiology/*genetics/immunology
MH  - Czech Republic
MH  - Female
MH  - Genotype
MH  - HLA-DQ Antigens/immunology
MH  - HLA-DR Antigens/immunology
MH  - Humans
MH  - Infectious Disease Transmission, Vertical
MH  - Male
MH  - Middle Aged
MH  - Narcolepsy/complications/*genetics/immunology
MH  - Pedigree
EDAT- 1998/02/11 00:00
MHDA- 1998/02/11 00:01
CRDT- 1998/02/11 00:00
PHST- 1998/02/11 00:00 [pubmed]
PHST- 1998/02/11 00:01 [medline]
PHST- 1998/02/11 00:00 [entrez]
AID - 10.1093/sleep/20.11.1021 [doi]
PST - ppublish
SO  - Sleep. 1997 Nov;20(11):1021-6. doi: 10.1093/sleep/20.11.1021.