PMID- 9457505
OWN - NLM
STAT- MEDLINE
DCOM- 19980326
LR  - 20111117
IS  - 1015-8146 (Print)
IS  - 1015-8146 (Linking)
VI  - 8
IP  - 4
DP  - 1997
TI  - Interstitial deletion 2p accompanied by marker chromosome formation of the 
      deleted segment resulting in a stable acentric marker chromosome.
PG  - 341-3
AB  - We reexamined a moderately mentally retarded patient with mild dysmorphism 
      previously described with de novo 47,XY, del(2)(p11;p21), +acefr. Using 
      fluorescence in situ hybridization (FISH), we now confirm the chromosome 2 nature 
      of the extra marker resulting from interstitial deletion of del(2)(p11;p21) as 
      well the lack alpha satellite DNA pattern. The authors suggest that a 
      reactivation process of a latent centromere may explain the origin of this stable 
      extra marker.
FAU - Petit, P
AU  - Petit P
AD  - Center for Human Genetics, University Hospital of Leuven, Belgium.
FAU - Fryns, J P
AU  - Fryns JP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Switzerland
TA  - Genet Couns
JT  - Genetic counseling (Geneva, Switzerland)
JID - 9015261
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Abnormalities, Multiple/*genetics
MH  - Adult
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 2
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Intellectual Disability/*genetics
MH  - Male
EDAT- 1997/01/01 00:00
MHDA- 1998/02/11 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/02/11 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PST - ppublish
SO  - Genet Couns. 1997;8(4):341-3.