PMID- 9458074
OWN - NLM
STAT- MEDLINE
DCOM- 19980224
LR  - 20061115
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 58
IP  - 3
DP  - 1998 Feb 1
TI  - Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, 
      malignant tumors of the endocrine pancreas.
PG  - 377-9
AB  - Endocrine pancreatic tumors are rare neoplasms that occur sporadically or as part 
      of a multiple endocrine neoplasia type 1 (MEN1) syndrome. Germ-line mutations of 
      the MEN1 gene, located at 11q13, have been demonstrated in MEN1 kindreds, and 
      loss of heterozygosity (LOH) on 11q13 together with somatic MEN1 mutations have 
      been detected in 20% of nonfamilial parathyroid tumors. Here, we examine 11 
      non-MEN1 malignant tumors of the endocrine pancreas, 9 nonfunctioning tumors, and 
      2 glucagonomas. LOH of at least one informative locus on 11q13 was found in 70% 
      of the tumors. Three tumors displayed somatic mutations of the MEN1 gene together 
      with LOH on 11q13, whereas the corresponding germ-line DNA was normal. These 
      findings support the hypothesis that MEN1 gene mutations contribute to the 
      tumorigenesis of nonfamilial, malignant endocrine pancreatic tumors.
FAU - Hessman, O
AU  - Hessman O
AD  - Department of Surgery, University Hospital, Uppsala, Sweden. 
      ola.hessman@kirurgi.uu.se
FAU - Lindberg, D
AU  - Lindberg D
FAU - Skogseid, B
AU  - Skogseid B
FAU - Carling, T
AU  - Carling T
FAU - Hellman, P
AU  - Hellman P
FAU - Rastad, J
AU  - Rastad J
FAU - Akerstrom, G
AU  - Akerstrom G
FAU - Westin, G
AU  - Westin G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA, Neoplasm)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosomes, Human, Pair 11/genetics
MH  - DNA, Neoplasm/genetics
MH  - Female
MH  - Glucagonoma/*genetics
MH  - Humans
MH  - Loss of Heterozygosity
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/deficiency/*genetics
MH  - Pancreatic Neoplasms/*genetics
MH  - Polymerase Chain Reaction
MH  - *Proto-Oncogene Proteins
EDAT- 1998/02/11 00:00
MHDA- 1998/02/11 00:01
CRDT- 1998/02/11 00:00
PHST- 1998/02/11 00:00 [pubmed]
PHST- 1998/02/11 00:01 [medline]
PHST- 1998/02/11 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1998 Feb 1;58(3):377-9.