PMID- 9459178
OWN - NLM
STAT- MEDLINE
DCOM- 19980227
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 121
IP  - 1
DP  - 1997 Dec 16
TI  - Non-random loss of chromosome 3 during transition of Helicobacter 
      pylori-associated gastric MALT to B-cell MALT lymphoma revealed by fluorescence 
      in situ hybridization.
PG  - 83-90
AB  - Acquired gastric mucosa-associated lymphoid tissue (MALT) accumulates as a result 
      of long-standing Helicobacter pylori (H. pylori) infection and from this acquired 
      MALT, low-grade B-cell MALT lymphoma may develop. Carcinogenesis is a multistep, 
      multifactorial process involving the progressive accumulation of genetic changes. 
      To determine whether numerical chromosomal alterations are involved in the 
      transition of H. pylori-associated human gastric MALT to low-grade B-cell MALT 
      lymphoma, frozen biopsy specimens prospectively obtained from H. pylori positive 
      gastric MALT and gastric MALT lymphoma patients, as well as normal control 
      patients (normal gastroscopy/gastric mucosal histology/H. pylori negative), were 
      analyzed by fluorescence in situ hybridization (FISH). Fluorescent, directly 
      labeled alpha-satellite DNA probes, specific for the centromeres of chromosomes 
      1, 3, 4, 11, 17 and Y were used in this study. The non-random loss of chromosome 
      3 was detected in two MALT patients and in all five MALT lymphoma patients. 
      Trisomy 17 was detected in one MALT patient and one MALT lymphoma patient. 
      Trisomy 1 was detected in a single MALT lymphoma patient as was trisomy 3. None 
      of the MALT patients had trisomy 3 or trisomy 1. Monosomy 17 was noted in one 
      MALT lymphoma patient. Clonal aneusomy was not observed in any patient for 
      chromosomes Y, 4 or 11. These results suggest that the consistent loss of 
      chromosome 3 may be an important genetic alteration in the transformation of H. 
      pylori-associated gastric MALT into low-grade B-cell gastric MALT lymphoma.
FAU - Banerjee, S K
AU  - Banerjee SK
AD  - Research Division (151), Midwest Biomedical Research Foundation, V.A. Medical 
      Center, Kansas City, MO 64128-2226, USA.
FAU - Weston, A P
AU  - Weston AP
FAU - Persons, D L
AU  - Persons DL
FAU - Campbell, D R
AU  - Campbell DR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 3
MH  - Chromosomes, Human, Pair 4
MH  - Helicobacter Infections/*pathology
MH  - *Helicobacter pylori
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Male
MH  - Middle Aged
MH  - Monosomy
MH  - Precancerous Conditions/*genetics
MH  - Stomach/microbiology/pathology
MH  - Y Chromosome
EDAT- 1998/02/12 00:00
MHDA- 1998/02/12 00:01
CRDT- 1998/02/12 00:00
PHST- 1998/02/12 00:00 [pubmed]
PHST- 1998/02/12 00:01 [medline]
PHST- 1998/02/12 00:00 [entrez]
AID - S0304-3835(97)00344-3 [pii]
AID - 10.1016/s0304-3835(97)00344-3 [doi]
PST - ppublish
SO  - Cancer Lett. 1997 Dec 16;121(1):83-90. doi: 10.1016/s0304-3835(97)00344-3.