PMID- 9459504
OWN - NLM
STAT- MEDLINE
DCOM- 19980313
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 51
IP  - 1
DP  - 1998 Jan
TI  - CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis.
PG  - 62-6
AB  - The genetic susceptibility to rheumatoid arthritis is conferred by genes in the 
      human leukocyte antigen (HLA) region on chromosome 6, but additional genes may be 
      involved to determine disease susceptibility. We have studied the distribution of 
      the CTLA4 exon 1 polymorphism (49 A/G) in rheumatoid arthritis. This dimorphism 
      at codon 17 results in an amino acid exchange (Thr/Ala) in the leader peptide of 
      the expressed protein and was analyzed by PCR, SSCP and RFLP in 258 Caucasian 
      rheumatoid arthritis patients and 456 controls. Rheumatoid arthritis patients 
      were characterized by a decreased frequency of homozygotes for the Thr-17 
      substitution (32% versus 39%) and an overrepresentation of patients heterozygous 
      for the Thr/Ala substitution (54% versus 46%). Gene frequencies for the Ala/Thr 
      substitution differed only marginally from controls. In contrast, analyses of the 
      CTLA4 exon 1 polymorphism with respect to HLA-DRB1*04 revealed significantly more 
      patients with Ala in the homozygous (19% versus 15% controls) or heterozygous 
      state (54% versus 39% controls) and less homozygous for Thr (27% versus 46% 
      controls), with a particular increase of Ala/Ala genotypes among rheumatoid 
      arthritis patients carrying the HLA-DRB1*0401 subtype. Among HLA-DRB1*04 negative 
      rheumatoid arthritis patients, we observed no difference between the allele 
      frequencies of the Ala-17 or Thr-17 substitution.
FAU - Seidl, C
AU  - Seidl C
AD  - Institute of Transfusion Medicine and Immunohematology, Red Cross Blood Donor 
      Service, Hessen, Germany.
FAU - Donner, H
AU  - Donner H
FAU - Fischer, B
AU  - Fischer B
FAU - Usadel, K H
AU  - Usadel KH
FAU - Seifried, E
AU  - Seifried E
FAU - Kaltwasser, J P
AU  - Kaltwasser JP
FAU - Badenhoop, K
AU  - Badenhoop K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Codon)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:01 antigen)
RN  - 0 (Immunoconjugates)
RN  - 2ZD004190S (Threonine)
RN  - 7D0YB67S97 (Abatacept)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Abatacept
MH  - Adult
MH  - Aged
MH  - Alanine/genetics
MH  - Antigens, CD
MH  - Antigens, Differentiation/*genetics
MH  - Arthritis, Rheumatoid/*genetics/immunology
MH  - CTLA-4 Antigen
MH  - *Codon
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - *Immunoconjugates
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single-Stranded Conformational
MH  - Threonine/genetics
EDAT- 1998/02/12 00:00
MHDA- 1998/02/12 00:01
CRDT- 1998/02/12 00:00
PHST- 1998/02/12 00:00 [pubmed]
PHST- 1998/02/12 00:01 [medline]
PHST- 1998/02/12 00:00 [entrez]
AID - 10.1111/j.1399-0039.1998.tb02947.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1998 Jan;51(1):62-6. doi: 10.1111/j.1399-0039.1998.tb02947.x.