PMID- 9459626
OWN - NLM
STAT- MEDLINE
DCOM- 19980317
LR  - 20151119
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 7
IP  - 6
DP  - 1997 Dec
TI  - CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese.
PG  - 843-6
AB  - Susceptibility to Graves' disease (GD) is determined by environmental and genetic 
      factors. The genetic susceptibility to GD is conferred by genes in the human 
      leukocyte antigen (HLA), and several other genes unlinked to HLA are thought to 
      contribute to the development of GD. Three recent papers described the 
      association of GD with the CTLA-4 gene. CTLA-4 is a candidate gene for T-cell 
      mediated autoimmune diseases because it is a negative regulator of T-cell 
      proliferation. As CTLA-4 association with GD may be influenced by the racial 
      composition of the population, it is important to study it in other ethnic 
      groups. We investigated the distribution of CTLA-4 gene polymorphism in 153 
      Japanese patients with GD (35 males and 118 females) and 200 controls (96 males 
      and 104 females). An A/G transition at position 49 of exon 1 was analyzed by the 
      polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) 
      method. The distribution of genotype frequencies differs between GD and controls 
      (chi2 = 9.46, 2 degrees of freedom, p < 0.01). The presence of at least one G 
      allele (GG or AG) conferred an odds ratio of 2.64 (95% CI = 1.92-3.36). The 
      present study supported the association of the CTLA-4 gene with GD in Japanese 
      and showed that the CTLA4 gene could be one of the non-HLA linked susceptibility 
      genes for GD.
FAU - Yanagawa, T
AU  - Yanagawa T
AD  - Department of Medicine, Nerima General Hospital, Tokyo, Japan.
FAU - Taniyama, M
AU  - Taniyama M
FAU - Enomoto, S
AU  - Enomoto S
FAU - Gomi, K
AU  - Gomi K
FAU - Maruyama, H
AU  - Maruyama H
FAU - Ban, Y
AU  - Ban Y
FAU - Saruta, T
AU  - Saruta T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Immunoconjugates)
RN  - 7D0YB67S97 (Abatacept)
SB  - IM
MH  - Abatacept
MH  - Antigens, CD
MH  - Antigens, Differentiation/*genetics
MH  - CTLA-4 Antigen
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Gene Frequency
MH  - Genes/*genetics
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Graves Disease/epidemiology/*genetics
MH  - Humans
MH  - *Immunoconjugates
MH  - Japan/epidemiology
MH  - Male
MH  - Polymorphism, Genetic
MH  - Sex Factors
EDAT- 1998/02/12 00:00
MHDA- 1998/02/12 00:01
CRDT- 1998/02/12 00:00
PHST- 1998/02/12 00:00 [pubmed]
PHST- 1998/02/12 00:01 [medline]
PHST- 1998/02/12 00:00 [entrez]
AID - 10.1089/thy.1997.7.843 [doi]
PST - ppublish
SO  - Thyroid. 1997 Dec;7(6):843-6. doi: 10.1089/thy.1997.7.843.