PMID- 9462837
OWN - NLM
STAT- MEDLINE
DCOM- 19980224
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 421
IP  - 1
DP  - 1998 Jan 2
TI  - The carboxyl-terminal domain of insulin-like growth factor-I receptor interacts 
      with the insulin receptor and activates its protein tyrosine kinase.
PG  - 45-9
AB  - Receptors for insulin and insulin-like growth factor-I (IR and IGFIR) consisting 
      of the alpha2beta2 structure are protein tyrosine kinases (PTKs). 
      Carboxyl-terminal (CT) domains of their beta subunits are structurally diverse 
      while the PTK domains share the highest homology. Interactions between CT and PTK 
      domains of IR and IGFIR were studied by means of PTK activity, fluorescence 
      energy transfer or surface plasmon resonance using BIAcore. We present evidence 
      that IGFIR CT directly interacts with both IGFIR and IR. Although binding to both 
      receptors, stimulation of PTK activity only occurs with IR but not IGFIR.
FAU - Li, S
AU  - Li S
AD  - Department of Molecular Biology, Beckman Research Institute of the City of Hope, 
      Duarte, CA 91010, USA.
FAU - Termini, J
AU  - Termini J
FAU - Hayward, A
AU  - Hayward A
FAU - Siddle, K
AU  - Siddle K
FAU - Zick, Y
AU  - Zick Y
FAU - Koval, A
AU  - Koval A
FAU - LeRoith, D
AU  - LeRoith D
FAU - Fujita-Yamaguchi, Y
AU  - Fujita-Yamaguchi Y
LA  - eng
GR  - CA33572/CA/NCI NIH HHS/United States
GR  - DK34427/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Peptide Fragments)
RN  - 0 (Recombinant Proteins)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
RN  - EC 2.7.10.1 (Receptor, Insulin)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - Cell Line
MH  - Cell Membrane/metabolism
MH  - Cloning, Molecular
MH  - Enzyme Activation
MH  - Kinetics
MH  - Models, Molecular
MH  - Peptide Fragments/chemistry/metabolism
MH  - Polymerase Chain Reaction
MH  - Rats
MH  - Receptor Protein-Tyrosine Kinases/chemistry/*metabolism
MH  - Receptor, IGF Type 1/chemistry/*metabolism
MH  - Receptor, Insulin/chemistry/*metabolism
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Sequence Tagged Sites
MH  - Transfection
EDAT- 1998/02/14 00:00
MHDA- 1998/02/14 00:01
CRDT- 1998/02/14 00:00
PHST- 1998/02/14 00:00 [pubmed]
PHST- 1998/02/14 00:01 [medline]
PHST- 1998/02/14 00:00 [entrez]
AID - S0014579397015238 [pii]
AID - 10.1016/s0014-5793(97)01523-8 [doi]
PST - ppublish
SO  - FEBS Lett. 1998 Jan 2;421(1):45-9. doi: 10.1016/s0014-5793(97)01523-8.