PMID- 9463720
OWN - NLM
STAT- MEDLINE
DCOM- 19980403
LR  - 20190512
IS  - 0735-0414 (Print)
IS  - 0735-0414 (Linking)
VI  - 32
IP  - 6
DP  - 1997 Nov-Dec
TI  - Ethanol enhances medial amygdaloid induced inhibition of predatory attack 
      behaviour in the cat: role of GABAA receptors in the lateral hypothalamus.
PG  - 657-70
AB  - The present study tested the hypothesis that the suppressive effects of ethanol 
      upon predatory attack behaviour in the cat involve a pathway from the medial 
      amygdala to the lateral hypothalamus, and that these suppressive effects are 
      mediated by gamma-aminobutyric acid (GABAA) receptors located in the lateral 
      hypothalamus. Cannula electrodes were implanted into the lateral hypothalamus for 
      elicitation of predatory attack behaviour and for microinjections of the GABAA 
      receptor antagonist, bicuculline. Monopolar stimulating electrodes were implanted 
      into the medial amygdala from which subseizure levels of electrical stimulation 
      suppressed predatory attack behaviour. In the first phase of the study, we 
      compared response latencies for predatory attack behaviour following single 
      stimulation of the lateral hypothalamus alone with those following paired trials 
      of dual stimulation of the medial amygdala plus lateral hypothalamus. Dual 
      stimulation significantly suppressed predatory attack. In the second phase of the 
      study, peripheral ethanol administration (in doses of 0.01, 0.5 and 1.0 g/kg, 
      i.p.) enhanced the suppressive effects of medial amygdaloid stimulation in a 
      dose- and time-dependent manner in which peak effects were obtained 60 min 
      post-injection. In the third phase of the study, bicuculline (0.15 nmol) was 
      microinjected into the lateral hypothalamus both prior to and following paired 
      trials of dual stimulation. Drug infusion blocked the suppressive effects of 
      medial amygdaloid stimulation upon predatory attack behaviour elicited from the 
      lateral hypothalamus, indicating the importance of GABAA receptors in mediating 
      this suppression. In the fourth phase of the study, bicuculline, microinjected 
      into the lateral hypothalamus at the time when ethanol's effects were maximal 
      (i.e. 60-80 min post-ethanol administration), totally blocked the suppressive 
      effects of medial amygdaloid stimulation as well as the enhancing effects of 
      ethanol upon medial amygdaloid suppression of this form of aggressive behaviour. 
      In the last phase of the study, bicuculline (0.15 nmol) infusion into the lateral 
      hypothalamus significantly reduced the suppressive effects of ethanol (1.0 g/kg, 
      i.p.) upon predatory attack behaviour elicited from the lateral hypothalamus. 
      These results support the hypothesis that ethanol's suppressive effects upon 
      predatory attack behaviour in the cat are mediated, at least in part, by GABAA 
      receptors in the lateral hypothalamus. The present and recent findings in our 
      laboratory support the view that GABAA receptors in the lateral hypothalamus are 
      activated, in turn, by a GABAergic pathway which arises from the medial 
      hypothalamus whose neurons receive inputs from the medial amygdala.
FAU - Han, Y
AU  - Han Y
AD  - Department of Neurosciences, University of Medicine & Dentistry of New Jersey-New 
      Jersey Medical School, Newark 07103, USA.
FAU - Shaikh, M B
AU  - Shaikh MB
FAU - Siegel, A
AU  - Siegel A
LA  - eng
GR  - NS07941-26/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Alcohol Alcohol
JT  - Alcohol and alcoholism (Oxford, Oxfordshire)
JID - 8310684
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (GABA Antagonists)
RN  - 0 (Receptors, GABA-A)
RN  - 3K9958V90M (Ethanol)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Amygdala/anatomy & histology/*drug effects/*physiology
MH  - Animals
MH  - Bicuculline/pharmacology
MH  - Cats
MH  - Central Nervous System Depressants/*pharmacology
MH  - Drug Interactions
MH  - Electric Stimulation
MH  - Electrodes, Implanted
MH  - Ethanol/*pharmacology
MH  - Female
MH  - GABA Antagonists/pharmacology
MH  - Hypothalamic Area, Lateral/*drug effects/*physiology
MH  - Male
MH  - Microinjections
MH  - Neural Pathways/drug effects/physiology
MH  - Predatory Behavior/*drug effects/*physiology
MH  - Receptors, GABA-A/*drug effects/*physiology
EDAT- 1998/02/17 00:00
MHDA- 1998/02/17 00:01
CRDT- 1998/02/17 00:00
PHST- 1998/02/17 00:00 [pubmed]
PHST- 1998/02/17 00:01 [medline]
PHST- 1998/02/17 00:00 [entrez]
AID - 10.1093/oxfordjournals.alcalc.a008316 [doi]
PST - ppublish
SO  - Alcohol Alcohol. 1997 Nov-Dec;32(6):657-70. doi: 
      10.1093/oxfordjournals.alcalc.a008316.