PMID- 9464634
OWN - NLM
STAT- MEDLINE
DCOM- 19980424
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 238
IP  - 3
DP  - 1997 Dec 5
TI  - Contributions of AMPA and GABA(A) receptors to the induction of NMDAR-dependent 
      LTP in CA1.
PG  - 119-22
AB  - The contributions of (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic 
      acid (AMPA) and gamma-aminobutyric acid (GABA[A]) receptors in the induction of 
      long-term potentiation (LTP) have been studied in the CA1 region of the rat 
      hippocampus. The results suggest that: (1) in physiological conditions, AMPARs 
      are necessary for the induction of N-methyl-D-aspartate receptor 
      (NMDAR)-dependent LTP since LTP cannot be elicited in the presence of the AMPAR 
      antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Although a 
      NMDAR-dependent LTP occurs in the presence of a GABA(A) antagonist and high 
      concentrations of divalents cations, blockade of AMPARs leads to a 
      voltage-dependent calcium channels (VDCC)-dependent LTP since its induction is 
      blocked by nifedipine and not by APV. (2) The bicarbonate-induced GABA(A) 
      receptor-mediated depolarizing response is not necessary in the induction of 
      NMDAR-dependent or VDCC-dependent LTP since induction of these two types of LTP 
      were not blocked by acetazolamide or in a nominally bicarbonate-free solution.
FAU - Debray, C
AU  - Debray C
AD  - Institut National de la Sante et de la Recherche Medicale U-29, Paris, France.
FAU - Diabira, D
AU  - Diabira D
FAU - Gaiarsa, J L
AU  - Gaiarsa JL
FAU - Ben-Ari, Y
AU  - Ben-Ari Y
FAU - Gozlan, H
AU  - Gozlan H
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, GABA-A)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - I9ZF7L6G2L (Nifedipine)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Animals
MH  - Bicuculline/pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects
MH  - Hippocampus/drug effects/*physiology
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/*drug effects
MH  - Male
MH  - Nifedipine/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, AMPA/*physiology
MH  - Receptors, GABA-A/*physiology
EDAT- 1998/02/17 00:00
MHDA- 1998/02/17 00:01
CRDT- 1998/02/17 00:00
PHST- 1998/02/17 00:00 [pubmed]
PHST- 1998/02/17 00:01 [medline]
PHST- 1998/02/17 00:00 [entrez]
AID - S0304-3940(97)00865-3 [pii]
AID - 10.1016/s0304-3940(97)00865-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 1997 Dec 5;238(3):119-22. doi: 10.1016/s0304-3940(97)00865-3.