PMID- 9464656
OWN - NLM
STAT- MEDLINE
DCOM- 19980504
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 238
IP  - 1-2
DP  - 1997 Nov 28
TI  - TNF-alpha expressed in the brain of transgenic mice lowers central tyroxine 
      hydroxylase immunoreactivity and alters grooming behavior.
PG  - 65-8
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a cytokine involved in a wide range of 
      biological effects both in physiological and non-physiological conditions. It is 
      also produced in the central nervous system (CNS) where it has been implicated in 
      reparative processes after traumatic injuries and in CNS demyelination, 
      neurodegeneration and inflammation. Using transgenic mice (Tg-m) expressing 
      TNF-alpha specifically in the CNS, we showed that the overexpression of this 
      cytokine reduced tyroxine hydroxylase immunoreactivity (TH-ir) in the 
      caudate-putamen and in the dorsomedial hypothalamic areas and impaired grooming 
      behavior. We also showed that this behavior is increased following anti-nerve 
      growth factor injection. These findings support the hypothesis, proposed by 
      others, that TNF-alpha is involved in the degenerative processes which occur in 
      Parkinson's disease.
FAU - Aloe, L
AU  - Aloe L
AD  - Institute of Neurobiology, CNR, Rome, Italy. aloe@biocell.irmkant.rm.cnr.it
FAU - Fiore, M
AU  - Fiore M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain/*metabolism
MH  - Caudate Nucleus/metabolism
MH  - Female
MH  - Grooming/drug effects/*physiology
MH  - Hypothalamus/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Nerve Growth Factors/pharmacology
MH  - Putamen/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism/*physiology
MH  - Tyrosine 3-Monooxygenase/metabolism
EDAT- 1998/02/17 00:00
MHDA- 1998/02/17 00:01
CRDT- 1998/02/17 00:00
PHST- 1998/02/17 00:00 [pubmed]
PHST- 1998/02/17 00:01 [medline]
PHST- 1998/02/17 00:00 [entrez]
AID - S0304-3940(97)00850-1 [pii]
AID - 10.1016/s0304-3940(97)00850-1 [doi]
PST - ppublish
SO  - Neurosci Lett. 1997 Nov 28;238(1-2):65-8. doi: 10.1016/s0304-3940(97)00850-1.