PMID- 9465907
OWN - NLM
STAT- MEDLINE
DCOM- 19980304
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 78
IP  - 3-4
DP  - 1997
TI  - Molecular cloning of a novel gene similar to myeloid antigen CD33 and its 
      specific expression in placenta.
PG  - 295-300
AB  - We have isolated a novel gene that encodes a protein sharing significant 
      similarity with myeloid antigen CD33. The complete cDNA contains an open reading 
      frame of 1,326 nucleotides encoding 442 amino acids. The deduced amino acid 
      sequence indicates that this molecule belongs to the immunoglobulin (Ig) 
      superfamily and is likely to be a new member of the sialoadhesin sub-family. It 
      is composed of three Ig-like domains; its high degree of similarity to CD33 (70% 
      identity) in the first and second of these domains implies that the 
      placenta-specific gene product is likely to be associated with cell-cell 
      interaction. Northern-blot analysis revealed transcripts of four distinct sizes, 
      7.5 kb, 5.0 kb, 4.1 kb, and 2.0 kb, specifically in the placenta. Consequently, 
      we termed this gene CD33L (CD33 antigen-like). An alternatively-spliced 
      transcript encoding a 342-amino-acid peptide which lacked the transmembrane 
      region and the cytoplasmic tail was also isolated. We mapped CD33L by 
      fluorescence in situ hybridization (FISH) to human chromosome 19q13.3, where the 
      CD33 gene is also located.
FAU - Takei, Y
AU  - Takei Y
AD  - Laboratory of Molecular Medicine, University of Tokyo, Japan.
FAU - Sasaki, S
AU  - Sasaki S
FAU - Fujiwara, T
AU  - Fujiwara T
FAU - Takahashi, E
AU  - Takahashi E
FAU - Muto, T
AU  - Muto T
FAU - Nakamura, Y
AU  - Nakamura Y
LA  - eng
SI  - GENBANK/D86358
SI  - GENBANK/D86359
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CD33 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - 0 (Sialic Acid Binding Ig-like Lectin 3)
RN  - 0 (Sialoglycoproteins)
SB  - IM
MH  - Alternative Splicing
MH  - Antigens, CD/*genetics
MH  - Antigens, Differentiation, Myelomonocytic/*genetics
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Cell Adhesion Molecules/*genetics
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 19
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - Placenta/*physiology
MH  - RNA, Messenger/analysis
MH  - Sequence Homology, Amino Acid
MH  - Sialic Acid Binding Ig-like Lectin 3
MH  - Sialoglycoproteins/genetics
EDAT- 1997/01/01 00:00
MHDA- 1998/02/18 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/02/18 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1159/000134676 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1997;78(3-4):295-300. doi: 10.1159/000134676.