PMID- 9465998
OWN - NLM
STAT- MEDLINE
DCOM- 19980311
LR  - 20190914
IS  - 0148-5016 (Print)
IS  - 0148-5016 (Linking)
VI  - 40
IP  - 1
DP  - 1998 Jan-Feb
TI  - Preconceptional sex selection: past, present, and future.
PG  - 3-14
AB  - Predetermination of sex in human and in farm animals is reviewed. Preconceptional 
      sex selection has generated great interest and controversy over the years. 
      Medical and commercial benefits outweigh the ethical issues. Technology has not 
      yet provided a routine method for separating the X- and Y-chromosome-bearing 
      sperm. Flow cytometry is the only technique that produces a clinically 
      significant enrichment of X- or Y-bearing spermatozoa However, concern has been 
      raised about the methodological implications of the flow technique because of the 
      use of DNA stains and UV light. Some other techniques, such as gradient columns, 
      appear to produce a slight enrichment of one type of sperm over the other, but 
      this level of enrichment appears unlikely to affect the sex ratio at birth. It 
      thus remains speculative whether 100% pure preparation of X or Y sperm can be 
      obtained unless a major improvement in methodology is achieved. Fluorescence in 
      situ hybridization (FISH) and polymerase chain reaction (PCR) are currently the 
      methods of choice for evaluating the validity of the sex selection procedure. In 
      view of the extraordinary pace of the technological and scientific progress, it 
      can be expected that the clinical and commercial application of the technology of 
      preconceptional sex selection by X and Y sperm separation will be a reality in 
      near future.
FAU - Hossain, A M
AU  - Hossain AM
AD  - Department of Obstetrics and Gynecology, University of South Alabama, Mobile 
      36688, USA.
FAU - Barik, S
AU  - Barik S
FAU - Rizk, B
AU  - Rizk B
FAU - Thorneycroft, I H
AU  - Thorneycroft IH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Arch Androl
JT  - Archives of andrology
JID - 7806755
SB  - IM
MH  - Animals
MH  - Ethics, Medical
MH  - Humans
MH  - Sex Preselection/*methods/veterinary
RF  - 92
EDAT- 1998/02/18 00:00
MHDA- 1998/02/18 00:01
CRDT- 1998/02/18 00:00
PHST- 1998/02/18 00:00 [pubmed]
PHST- 1998/02/18 00:01 [medline]
PHST- 1998/02/18 00:00 [entrez]
AID - 10.3109/01485019808987923 [doi]
PST - ppublish
SO  - Arch Androl. 1998 Jan-Feb;40(1):3-14. doi: 10.3109/01485019808987923.