PMID- 9469394
OWN - NLM
STAT- MEDLINE
DCOM- 19980312
LR  - 20190818
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 17
IP  - 1
DP  - 1998 Jan
TI  - Risk of recurrent seizures after a primary human herpesvirus 6-induced febrile 
      seizure.
PG  - 43-8
AB  - OBJECTIVE: To test the hypothesis that children experiencing first febrile 
      seizures caused by human herpesvirus 6 (HHV-6) have an increased risk for 
      recurrent seizures when compared with children experiencing first febrile 
      seizures attributed to other illnesses. DESIGN AND PARTICIPANTS: Descriptive 
      prospective study of 36 HHV-6 culture-positive children and a matched subgroup of 
      86 HHV-6 culture-negative children, all of whom had their first febrile seizures 
      evaluated in a tertiary care emergency department and were followed for at least 
      12 months, with an average follow-up of 35.7 months. PRIMARY OUTCOME MEASURE: The 
      recurrence of seizures among HHV-6 culture-positive and HHV-6 culture-negative 
      children with no known previous neurologic deficits. RESULTS: A decreased 
      incidence of recurrent seizures occurred in children whose first febrile seizures 
      were caused by HHV-6. Twenty percent of HHV-6 culture-positive children and 40% 
      of HHV-6 culture-negative children (P < 0.038) experienced a recurrent seizure 
      within 1 year of their first febrile seizure. The mean time to recurrence within 
      12 months was 8.6 months for children with HHV-6 infection and 3.8 months (P < 
      0.001) for children without HHV-6 infection. Most recurrent seizures occurred 
      within 12 months of a first febrile seizure for both HHV-6-positive and 
      HHV-6-negative children (88 and 91%). CONCLUSIONS: Children who had their first 
      febrile seizures caused by primary HHV-6 infection did not demonstrate an 
      increased risk for recurrent seizures when compared with children whose first 
      febrile seizures were from other etiologies.
FAU - Jee, S H
AU  - Jee SH
AD  - Department of Pediatrics, University of Rochester School of Medicine and 
      Dentistry, NY, USA.
FAU - Long, C E
AU  - Long CE
FAU - Schnabel, K C
AU  - Schnabel KC
FAU - Sehgal, N
AU  - Sehgal N
FAU - Epstein, L G
AU  - Epstein LG
FAU - Hall, C B
AU  - Hall CB
LA  - eng
GR  - 5-MO1-RR-000-44/RR/NCRR NIH HHS/United States
GR  - R01 A 133020-02/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
SB  - IM
MH  - Child, Preschool
MH  - Herpesviridae Infections/*complications
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Infant
MH  - Prospective Studies
MH  - Recurrence
MH  - Risk
MH  - Seizures/*etiology
MH  - Seizures, Febrile/*etiology
EDAT- 1998/02/20 00:00
MHDA- 1998/02/20 00:01
CRDT- 1998/02/20 00:00
PHST- 1998/02/20 00:00 [pubmed]
PHST- 1998/02/20 00:01 [medline]
PHST- 1998/02/20 00:00 [entrez]
AID - 10.1097/00006454-199801000-00010 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 1998 Jan;17(1):43-8. doi: 10.1097/00006454-199801000-00010.