PMID- 9469480
OWN - NLM
STAT- MEDLINE
DCOM- 19980226
LR  - 20190516
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 63
IP  - 1
DP  - 1998 Jan
TI  - Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan 
      peritonitis model.
PG  - 108-16
AB  - The role of monocyte chemoattractant protein-1 (MCP-1) in the recruitment of 
      blood-derived monocytes in a model of zymosan peritoneal inflammation was 
      investigated. After zymosan injection (1 mg) a rapid influx of polymorphonuclear 
      leukocytes (PMN) and monocytes into the peritoneal cavity associated with mouse 
      MCP-1 (JE) gene activation and protein secretion in the exudates occurred. MCP-1 
      production (maximal at 4 h) preceded the accumulation of monocytes 
      (F4/80-positive cells, maximally recovered between 16 and 24 h). Treatment of 
      mice with a single injection of anti-mouse MCP-1 antibody inhibited 16-h monocyte 
      accumulation by approximately 40%, however, a significant decrease in the number 
      of PMN was also measured. Finally, intraperitoneal injection of murine 
      recombinant MCP-1 (1 microg) produced a selective accumulation of monocytes 
      (F4/80-positive cells) into the peritoneal cavity. In conclusion, we show the 
      novel existence of a strict relationship between MCP-1 production and leukocyte 
      accumulation in this model of acute inflammation.
FAU - Ajuebor, M N
AU  - Ajuebor MN
AD  - Department of Biochemical Pharmacology, The William Harvey Research Institute, 
      London, United Kingdom.
FAU - Flower, R J
AU  - Flower RJ
FAU - Hannon, R
AU  - Hannon R
FAU - Christie, M
AU  - Christie M
FAU - Bowers, K
AU  - Bowers K
FAU - Verity, A
AU  - Verity A
FAU - Perretti, M
AU  - Perretti M
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glucocorticoids)
RN  - 0 (Macrophage-1 Antigen)
RN  - 5V9KLZ54CY (Vinblastine)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9010-72-4 (Zymosan)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Chemokine CCL2/*physiology
MH  - *Chemotaxis, Leukocyte
MH  - Dexamethasone/pharmacology
MH  - Disease Models, Animal
MH  - Glucocorticoids/pharmacology
MH  - Macrophage-1 Antigen/physiology
MH  - Male
MH  - Mice
MH  - Monocytes/*physiology
MH  - Peritonitis/*immunology/pathology
MH  - Vinblastine/pharmacology
MH  - Zymosan
EDAT- 1998/02/20 00:00
MHDA- 1998/02/20 00:01
CRDT- 1998/02/20 00:00
PHST- 1998/02/20 00:00 [pubmed]
PHST- 1998/02/20 00:01 [medline]
PHST- 1998/02/20 00:00 [entrez]
AID - 10.1002/jlb.63.1.108 [doi]
PST - ppublish
SO  - J Leukoc Biol. 1998 Jan;63(1):108-16. doi: 10.1002/jlb.63.1.108.