PMID- 9469800
OWN - NLM
STAT- MEDLINE
DCOM- 19980317
LR  - 20220309
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 279
IP  - 5354
DP  - 1998 Feb 20
TI  - Association of malaria parasite population structure, HLA, and immunological 
      antagonism.
PG  - 1173-7
AB  - Host-parasite coevolution has been likened to a molecular arms race, with 
      particular parasite genes evolving to evade specific host defenses. Study of the 
      variants of an antigenic epitope of Plasmodium falciparum that induces a 
      cytotoxic T cell response supports this view. In African children with malaria, 
      the variants present are influenced by the presence of a human leukocyte antigen 
      (HLA) type that restricts the immune response to this epitope. The distribution 
      of parasite variants may be further influenced by the ability of cohabiting 
      parasite strains to facilitate each other's survival by down-regulating cellular 
      immune responses, using altered peptide ligand antagonism.
FAU - Gilbert, S C
AU  - Gilbert SC
AD  - Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, 
      University of Oxford, Windmill Road, Oxford OX3 7BN, UK.
FAU - Plebanski, M
AU  - Plebanski M
FAU - Gupta, S
AU  - Gupta S
FAU - Morris, J
AU  - Morris J
FAU - Cox, M
AU  - Cox M
FAU - Aidoo, M
AU  - Aidoo M
FAU - Kwiatkowski, D
AU  - Kwiatkowski D
FAU - Greenwood, B M
AU  - Greenwood BM
FAU - Whittle, H C
AU  - Whittle HC
FAU - Hill, A V
AU  - Hill AV
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, Protozoan)
RN  - 0 (Epitopes)
RN  - 0 (HLA-B35 Antigen)
RN  - 0 (Ligands)
RN  - 0 (Protozoan Proteins)
RN  - 0 (circumsporozoite protein, Protozoan)
SB  - IM
CIN - Science. 1998 Feb 20;279(5354):1136. PMID: 9508687
MH  - Alleles
MH  - Animals
MH  - Antigens, Protozoan/genetics/*immunology
MH  - Biological Evolution
MH  - Child
MH  - Epitopes
MH  - Evolution, Molecular
MH  - Gambia
MH  - Genes, Protozoan
MH  - Genetic Variation
MH  - HLA-B35 Antigen/*immunology
MH  - Humans
MH  - Ligands
MH  - Malaria, Falciparum/*immunology/parasitology
MH  - Models, Biological
MH  - Plasmodium falciparum/genetics/*immunology
MH  - Protozoan Proteins/genetics/*immunology
MH  - T-Lymphocytes, Cytotoxic/*immunology
EDAT- 1998/03/21 00:00
MHDA- 1998/03/21 00:01
CRDT- 1998/03/21 00:00
PHST- 1998/03/21 00:00 [pubmed]
PHST- 1998/03/21 00:01 [medline]
PHST- 1998/03/21 00:00 [entrez]
AID - 10.1126/science.279.5354.1173 [doi]
PST - ppublish
SO  - Science. 1998 Feb 20;279(5354):1173-7. doi: 10.1126/science.279.5354.1173.