PMID- 9469879
OWN - NLM
STAT- MEDLINE
DCOM- 19980519
LR  - 20131121
IS  - 0147-6513 (Print)
IS  - 0147-6513 (Linking)
VI  - 38
IP  - 3
DP  - 1997 Dec
TI  - Immunoreactivity of roach, Rutilus rutilus, following laboratory exposure to 
      bleached pulp and paper mill effluents.
PG  - 266-71
AB  - In order to study immunomodulation, controlled laboratory experiments were 
      carried out with roach (Rutilus rutilus) exposed to bleached kraft mill effluent 
      (BKME) or spent bleach liquor (SBL) from two pulp and paper mills using 
      elementary chlorine and chlorine dioxide for bleaching. The total number of 
      immunoglobulin-secreting cells (ISC) and the number of specific 
      antibody-secreting cells (ASC) were determined by ELISPOT assay. Exposure to BKME 
      resulted in decreased numbers of ISC in the spleen. To study the capability of 
      response against foreign antigens the fish were immunized with bovine 
      gamma-globulin. Exposure to BKME or SBL reduced antigen-specific ASC response in 
      fish. Moreover, the suppression of ASC response did not require exposure prior to 
      immunization. Depuration of fish in clean water reveals that the 
      immunosuppression caused by BKME is reversible. The ASC response in the 
      BKME-pretreated fish returned to the same or even a higher level compared to 
      untreated immunized fish and, in addition, the number of ISC increased greatly. 
      The results of this study verify an earlier finding on poor antibody response due 
      to exposure in a lake contaminated with BKME. Exposure to SBL alone suppresses 
      antibody-mediated immunity, suggesting that compounds formed in bleaching are at 
      least partly responsible for immunotoxic effects.
FAU - Aaltonen, T M
AU  - Aaltonen TM
AD  - Department of Biological and Environmental Science, University of Jyvaskyla, 
      Jyvaskyla, Finland. tumiaa@jyu.fi
FAU - Valtonen, E T
AU  - Valtonen ET
FAU - Jokinen, E I
AU  - Jokinen EI
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Chlorine Compounds)
RN  - 0 (Disinfectants)
RN  - 0 (Immunoglobulins)
RN  - 0 (Industrial Waste)
RN  - 0 (Oxides)
RN  - 0 (Water Pollutants, Chemical)
RN  - 4R7X1O2820 (Chlorine)
RN  - 8061YMS4RM (chlorine dioxide)
SB  - IM
MH  - Animals
MH  - Chlorine/*toxicity
MH  - Chlorine Compounds/*toxicity
MH  - Cyprinidae/*metabolism
MH  - Disinfectants/*toxicity
MH  - Immune Tolerance/drug effects
MH  - Immunoglobulins/analysis
MH  - Industrial Waste
MH  - Oxides/*toxicity
MH  - Paper
MH  - Spleen/drug effects/immunology
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 1998/02/21 00:00
MHDA- 1998/02/21 00:01
CRDT- 1998/02/21 00:00
PHST- 1998/02/21 00:00 [pubmed]
PHST- 1998/02/21 00:01 [medline]
PHST- 1998/02/21 00:00 [entrez]
AID - S0147-6513(97)91588-8 [pii]
AID - 10.1006/eesa.1997.1588 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 1997 Dec;38(3):266-71. doi: 10.1006/eesa.1997.1588.