PMID- 9470146
OWN - NLM
STAT- MEDLINE
DCOM- 19980320
LR  - 20190909
IS  - 0165-1838 (Print)
IS  - 0165-1838 (Linking)
VI  - 67
IP  - 1-2
DP  - 1997 Dec 3
TI  - Functionally different neurons are organized topographically in the rostral 
      ventrolateral medulla of rabbits.
PG  - 67-78
AB  - To examine whether the sympatho-excitatory neurons in the rostral ventrolateral 
      medulla (RVLM) were divided into subgroups, gamma-amino-n-butyric acid (GABA) was 
      injected into multiple sites of the medulla while simultaneous recordings of 
      blood flows were made from the renal artery with an ultrasonic pulsed Doppler 
      flowmeter and from the ear skin and muscles of fore- and hind-limbs with laser 
      Doppler flow meters in urethane-anesthetized, vagotomized and immobilized 
      rabbits. The magnitude of the responses of mean systemic arterial pressure (MAP), 
      heart rate (HR) and conductance of each vascular bed, calculated by its blood 
      flow and MAP, were represented as a contour map of the ventral surface of the 
      medulla. Microinjection of GABA (50 mM, 9-27 nl) into the RVLM produced a 
      decrease in MAP (-27 +/- 10 mmHg) and HR (-14 +/- 7 beat min-1) and an increase 
      in the vascular conductance of the ear skin (ESC; 33 +/- 25 microliters min-1 100 
      g-1 (mmHg)-1), the fore-limb muscle (FLMC; 93 +/- 84 microliters min-1 100 g-1 
      (mmHg)-1), the hind-limb muscle (HLMC; 18 +/- 7 microliters min-1 100 g-1 
      (mmHg)-1) and the kidney (KC; 49 +/- 25 microliters min-1 (mmHg)-1). Comparing 
      the sites into which the injection of GABA evoked the maximal response of MAP 
      (the 'center' of the RVLM), the maximal responses of HR, ESC and KC were obtained 
      from caudal, caudo-medial and slightly rostral sites, respectively. In more than 
      half of cases, the maximal responses of FLMC and HLMC were obtained from the 
      'center' of the RVLM. These results indicated that the functionally different 
      sympatho-excitatory reticulospinal neurons are located at different sites in the 
      RVLM, although they considerably intermingle with each other.
FAU - Ootsuka, Y
AU  - Ootsuka Y
AD  - Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki-ken, Japan.
FAU - Terui, N
AU  - Terui N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Auton Nerv Syst
JT  - Journal of the autonomic nervous system
JID - 8003419
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Animals
MH  - Autonomic Fibers, Preganglionic/drug effects/physiology
MH  - Blood Pressure/drug effects/physiology
MH  - Female
MH  - Heart Rate/drug effects/physiology
MH  - Laser-Doppler Flowmetry
MH  - Male
MH  - Medulla Oblongata/blood supply/cytology/*physiology
MH  - Neurons/drug effects/*physiology
MH  - Rabbits
MH  - Regional Blood Flow/drug effects/physiology
MH  - Spinal Cord/blood supply/drug effects/physiology
MH  - gamma-Aminobutyric Acid/administration & dosage/pharmacology
EDAT- 1998/02/21 00:00
MHDA- 1998/02/21 00:01
CRDT- 1998/02/21 00:00
PHST- 1998/02/21 00:00 [pubmed]
PHST- 1998/02/21 00:01 [medline]
PHST- 1998/02/21 00:00 [entrez]
AID - S0165-1838(97)00094-5 [pii]
AID - 10.1016/s0165-1838(97)00094-5 [doi]
PST - ppublish
SO  - J Auton Nerv Syst. 1997 Dec 3;67(1-2):67-78. doi: 10.1016/s0165-1838(97)00094-5.