PMID- 9472678
OWN - NLM
STAT- MEDLINE
DCOM- 19980303
LR  - 20190512
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 111
IP  - 1
DP  - 1998 Jan
TI  - Beta2-glycoprotein I-dependent and -independent anticardiolipin antibody in 
      non-obese diabetic (NOD) mice.
PG  - 173-80
AB  - In the present study we investigate whether or not anticardiolipin antibody (aCL) 
      is produced in NOD mice, which is a representative animal model of 
      insulin-dependent diabetes mellitus (IDDM). We found that IgG class aCL appeared 
      in 6.9% of non-diabetic NOD mice at weeks 5-15. The rates increased with age to 
      31.6% at weeks 16-25 and 71.9% at weeks 26-35. In addition, the titre and 
      incidence of aCL were higher in diabetic mice than in non-diabetic mice. It was 
      also found that aCL in NOD mice involved beta2-glycoprotein I 
      (beta2-GPI)-dependent and -independent aCL, when beta2-GPI was added to the aCL 
      assay system. The IgG subclass of both beta2-GPI-dependent and -independent aCL 
      belonged exclusively to IgG2a. In addition, immunohistochemical studies revealed 
      the predominant accumulation of IgG2a- or IgG3-positive B lymphocytes within 
      insulitis. These results suggest that the autoimmunity in NOD mice may thus be 
      associated with Th1 predominant immunological response. In conclusion, aCL with 
      multiple antigenic specificity were produced in NOD mice along with the 
      development of insulitis and diabetes. NOD mice should thus be added to the list 
      of animal models possessing antiphospholipid antibody.
FAU - Anzai, K
AU  - Anzai K
AD  - Department of Laboratory Medicine, Fukuoka University School of Medicine, Japan.
FAU - Nagafuchi, S
AU  - Nagafuchi S
FAU - Niho, Y
AU  - Niho Y
FAU - Kikuchi, M
AU  - Kikuchi M
FAU - Ono, J
AU  - Ono J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Antibodies, Anticardiolipin)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
MH  - Animals
MH  - Antibodies, Anticardiolipin/*immunology
MH  - Diabetes Mellitus, Type 1/*immunology
MH  - Glycoproteins/*immunology
MH  - Immunoglobulin G/immunology
MH  - Immunohistochemistry
MH  - Membrane Glycoproteins/immunology
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Th1 Cells/immunology
MH  - beta 2-Glycoprotein I
PMC - PMC1904869
EDAT- 1998/02/24 00:00
MHDA- 1998/02/24 00:01
PMCR- 1999/01/01
CRDT- 1998/02/24 00:00
PHST- 1998/02/24 00:00 [pubmed]
PHST- 1998/02/24 00:01 [medline]
PHST- 1998/02/24 00:00 [entrez]
PHST- 1999/01/01 00:00 [pmc-release]
AID - 10.1046/j.1365-2249.1998.00476.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 1998 Jan;111(1):173-80. doi: 10.1046/j.1365-2249.1998.00476.x.