PMID- 9472682
OWN - NLM
STAT- MEDLINE
DCOM- 19980303
LR  - 20220310
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 111
IP  - 1
DP  - 1998 Jan
TI  - Effect of annexin-1 on experimental autoimmune encephalomyelitis (EAE) in the 
      rat.
PG  - 198-204
AB  - Annexin-1, a calcium-dependent phospholipid binding protein, has been shown to 
      act as an endogenous central neuroprotectant, notably against cerebral ischaemic 
      damage. In the present study we extend these findings to an animal model of 
      multiple sclerosis, EAE, and report that endogenous annexin-1 is expressed in 
      ED1+ macrophages and resident astrocytes localized within the lesions in the 
      central nervous system (CNS). Intracerebroventricular (i.c.v.) administration of 
      an NH2-terminal fragment spanning amino acids 1-188 of annexin-1 after the onset 
      of the clinical symptoms significantly reduced both the neurological severity as 
      well as weight loss of mild EAE. Immunoneutralization of endogenous brain 
      annexin-1 failed to exacerbate the clinical features of EAE. Thus, although the 
      role of endogenous annexin-1 in the pathogenesis of EAE remains to be determined, 
      our findings suggest that annexin-1 may be of therapeutic benefit to the 
      treatment of multiple sclerosis.
FAU - Huitinga, I
AU  - Huitinga I
AD  - Research Institute Neurosciences, Department of Pharmacology, Vrije Universiteit, 
      Amsterdam, The Netherlands.
FAU - Bauer, J
AU  - Bauer J
FAU - Strijbos, P J
AU  - Strijbos PJ
FAU - Rothwell, N J
AU  - Rothwell NJ
FAU - Dijkstra, C D
AU  - Dijkstra CD
FAU - Tilders, F J
AU  - Tilders FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Annexin A1)
SB  - IM
MH  - Animals
MH  - Annexin A1/*biosynthesis/*therapeutic use
MH  - Brain/metabolism/pathology
MH  - Encephalomyelitis, Autoimmune, Experimental/*drug therapy/metabolism/pathology
MH  - Macrophages/metabolism/pathology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Lew
PMC - PMC1904852
EDAT- 1998/02/24 00:00
MHDA- 1998/02/24 00:01
PMCR- 1999/01/01
CRDT- 1998/02/24 00:00
PHST- 1998/02/24 00:00 [pubmed]
PHST- 1998/02/24 00:01 [medline]
PHST- 1998/02/24 00:00 [entrez]
PHST- 1999/01/01 00:00 [pmc-release]
AID - 10.1046/j.1365-2249.1998.00490.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 1998 Jan;111(1):198-204. doi: 10.1046/j.1365-2249.1998.00490.x.