PMID- 9475238
OWN - NLM
STAT- MEDLINE
DCOM- 19980325
LR  - 20190516
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 36
IP  - 12
DP  - 1997 Dec
TI  - Chemokines in the bronchoalveolar lavage fluid of patients with sarcoidosis.
PG  - 856-60
AB  - We measured the levels of interleukin-8 (IL-8) and monocyte chemoattractant 
      protein-1 (MCP-1) in the bronchoalveolar lavage (BAL) fluids from 27 patients 
      with active pulmonary sarcoidosis and examined the relationship between chemokine 
      levels and some clinical manifestations. The levels of two chemokines were 
      assessed by enzyme-linked immunosorbent assay. There were significant positive 
      correlations between the absolute number of lymphocytes and MCP-1 levels. The 
      level of MCP-1 was significantly higher in the group with age at onset of over 50 
      year than that in the group with age at onset under 30 year. There were no 
      significant differences between the non-smokers and smokers, or among the groups 
      of patients classed according to stages. We conclude that MCP-1 can play an 
      important role in the pathogenesis and clinical course of pulmonary sarcoidosis, 
      although further analysis is needed to delineate the exact role of IL-8.
FAU - Sugiyama, Y
AU  - Sugiyama Y
AD  - Department of Pulmonary Medicine, Jichi Medical School, Tochigi.
FAU - Kasahara, T
AU  - Kasahara T
FAU - Mukaida, N
AU  - Mukaida N
FAU - Matsushima, K
AU  - Matsushima K
FAU - Kitamura, S
AU  - Kitamura S
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid/*chemistry
MH  - Chemokine CCL2/*analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Guinea Pigs
MH  - Humans
MH  - Interleukin-8/*analysis
MH  - Lymphocytes/pathology
MH  - Macrophages/pathology
MH  - Male
MH  - Middle Aged
MH  - Sarcoidosis, Pulmonary/complications/*metabolism/pathology
MH  - Smoking/adverse effects
EDAT- 1998/02/25 00:00
MHDA- 1998/02/25 00:01
CRDT- 1998/02/25 00:00
PHST- 1998/02/25 00:00 [pubmed]
PHST- 1998/02/25 00:01 [medline]
PHST- 1998/02/25 00:00 [entrez]
AID - 10.2169/internalmedicine.36.856 [doi]
PST - ppublish
SO  - Intern Med. 1997 Dec;36(12):856-60. doi: 10.2169/internalmedicine.36.856.