PMID- 9477142
OWN - NLM
STAT- MEDLINE
DCOM- 19980416
LR  - 20190914
IS  - 0920-1211 (Print)
IS  - 0920-1211 (Linking)
VI  - 29
IP  - 2
DP  - 1998 Jan
TI  - Zonisamide for progressive myoclonus epilepsy: long-term observations in seven 
      patients.
PG  - 109-14
AB  - Progressive myoclonic epilepsy (PME) syndromes are intractable to most 
      antiepileptic drugs (AED). The course of these diseases, results in almost total 
      dependency due to continuous myoclonias, repeated episodes of status epilepticus, 
      ataxia and dementia. The need for new treatment strategies is therefore 
      imperative. Zonisamide has previously been reported to be effective in two 
      patients with PME. Case reports of seven patients (ages 19-42) with 
      Unverricht-Lundborgs disease (ULD) and one Lafora Body Disease are presented. 
      Zonisamide was given at doses of 100-600 mg/day for a period of 2 to 3 years. 
      Concomitant AEDs were usually valproate and a benzodiazepine. Zonisamide 
      dramatically reduced the amount of myoclonias and generalized seizures. In three 
      of the cases, the initial dramatic effect on myoclonias wore off after 2-4 years 
      of treatment but patients still experienced moderate efficacy for generalized 
      tonic-clonic seizures. The dramatic reduction of stimulus sensitivity for light, 
      touch and startle by zonisamide was sustained in all patients with ULD. 
      Zonisamide may be a useful agent in the treatment of PME. Controlled clinical 
      trials are warranted to further investigate the antiepileptic effects of this 
      drug, in difficult to treat epileptic syndromes.
FAU - Kyllerman, M
AU  - Kyllerman M
AD  - Department of Pediatrics, Sahlgren University Hospital, Goteborg, Sweden.
FAU - Ben-Menachem, E
AU  - Ben-Menachem E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
RN  - 0 (Anticonvulsants)
RN  - 0 (Isoxazoles)
RN  - 459384H98V (Zonisamide)
SB  - IM
MH  - Adult
MH  - Anticonvulsants/*therapeutic use
MH  - Epilepsies, Myoclonic/*drug therapy
MH  - Female
MH  - Humans
MH  - Isoxazoles/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Time Factors
MH  - Zonisamide
EDAT- 1998/02/26 00:00
MHDA- 1998/02/26 00:01
CRDT- 1998/02/26 00:00
PHST- 1998/02/26 00:00 [pubmed]
PHST- 1998/02/26 00:01 [medline]
PHST- 1998/02/26 00:00 [entrez]
AID - S0920-1211(97)00069-7 [pii]
AID - 10.1016/s0920-1211(97)00069-7 [doi]
PST - ppublish
SO  - Epilepsy Res. 1998 Jan;29(2):109-14. doi: 10.1016/s0920-1211(97)00069-7.