PMID- 947978
OWN - NLM
STAT- MEDLINE
DCOM- 19761001
LR  - 20190723
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 58
IP  - 1 PT 1
DP  - 1976 Jul
TI  - Factors which influence late cutaneous allergic responses.
PG  - 60-8
AB  - Increased doses of ragweed antigen E, grass pollen extract, and the IgG of sheep 
      antiserum to human IgE (anti-IgE) were injected in intracutaneous tests in 
      humans. With increasing doses of reactants, in individual subjects, there were 
      the expected increases in the sizes of early wheal-and-flare responses; moreover, 
      there was an associated increase in the magnitude and the frequency of late 
      cutaneous allergic responses (LCAR). LCAR were shown to be a usual sequel to 
      allergic reactions of sufficient intensity. In persons with allergic 
      bronchopulmonary aspergillosis, cutaneous responses to Aspergillus fumigatus 
      allergen were compared with responses to other allergens and to anti-IgE; in 
      relation to early wheal-and-flare responses, the corresponding LCAR induced by A. 
      fumigatus were approximately the same size as those induced by the other 
      reactants. Skin reactions induced by the prick test method and by intracutaneous 
      injection were compared; for early responses of given sizes, there were 
      apparently equal tendencies to proceed to LCAR in reactions to allergen in the 
      two types of administration. In one subject, anti-IgE-induced responses in the 
      skin of a forearm with sensory denervation were compared with responses in the 
      other normally innervated forearm. At the denervated site was the expected 
      absence of the early flare but no apparent reduction in LCAR. Similarly, local 
      anesthesia immediately prior to anti-IgE eliminated the flare of the early 
      response but did not prevent the occurrence of a LCAR.
FAU - Umemoto, L
AU  - Umemoto L
FAU - Poothullil, J
AU  - Poothullil J
FAU - Dolovich, J
AU  - Dolovich J
FAU - Hargreave, F E
AU  - Hargreave FE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Antibodies)
RN  - 0 (Antigens)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Anesthesia, Local
MH  - Antibodies/administration & dosage
MH  - Antigens/administration & dosage
MH  - Aspergillosis/complications
MH  - Denervation
MH  - Humans
MH  - Hypersensitivity/complications/*diagnosis
MH  - Immunoglobulin E
MH  - Injections, Intradermal
MH  - Plant Extracts/administration & dosage
MH  - Poaceae/immunology
MH  - *Skin Tests
MH  - Time Factors
EDAT- 1976/07/01 00:00
MHDA- 1976/07/01 00:01
CRDT- 1976/07/01 00:00
PHST- 1976/07/01 00:00 [pubmed]
PHST- 1976/07/01 00:01 [medline]
PHST- 1976/07/01 00:00 [entrez]
AID - 0091-6749(76)90107-X [pii]
AID - 10.1016/0091-6749(76)90107-x [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 1976 Jul;58(1 PT 1):60-8. doi: 
      10.1016/0091-6749(76)90107-x.