PMID- 9481796
OWN - NLM
STAT- MEDLINE
DCOM- 19980324
LR  - 20220317
IS  - 0301-0082 (Print)
IS  - 0301-0082 (Linking)
VI  - 54
IP  - 2
DP  - 1998 Feb
TI  - Cortical modulation of the cardiovascular system.
PG  - 149-68
AB  - Cortical modulation of central cardiovascular control mechanisms has been 
      recognized for many decades. However, it is only recently that the mechanisms 
      underlying cortical influences on circulatory function have been systematically 
      examined. This review considers the view that certain regions of the cerebral 
      cortex, including the medial prefrontal cortex (MPFC) and insular cortex (IC), 
      participate in specific aspects of central circulatory control. Anatomical 
      investigations indicate that these cortical areas are connected with 
      hypothalamic, midbrain, pontine and medullary brain regions involved in 
      cardiovascular control. Lesions of the MPFC and IC have demonstrated modulation 
      of the activity of cardiovascular reflexes such as the baroreceptor heart rate 
      reflex and involvement in conditioned cardiovascular responses. 
      Electrophysiological studies have provided evidence that cortical regions are 
      able to influence premotor sympathoexcitatory vasomotor neurons within the 
      rostral ventrolateral medulla and subsequently alter sympathetic vasomotor tone. 
      Cortical regions such as the IC receive visceral sensory information arising from 
      baroreceptors and chemoreceptors within the cardiovascular system. In contrast, 
      the MPFC receives afferents predominantly from limbic sources, although its 
      outputs include structures associated with central sympathetic vasomotor control. 
      Cortical modulation of circulatory function has been demonstrated in man and may 
      underlie the cardiovascular components of a number of conditions. It is suggested 
      that cortical areas involved in visceral sensory or visceral motor processes 
      associated with circulatory function may be involved in generation of patterns of 
      cardiovascular responses specific for certain behaviours.
FAU - Verberne, A J
AU  - Verberne AJ
AD  - University of Melbourne, Department of Medicine, Austin and Repatriation Medical 
      Centre, Heidelberg, VIC, Australia. tonyv@austin.unimelb.edu.au
FAU - Owens, N C
AU  - Owens NC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Prog Neurobiol
JT  - Progress in neurobiology
JID - 0370121
SB  - IM
MH  - Afferent Pathways/physiology
MH  - Animals
MH  - Cardiovascular System/*innervation
MH  - Cerebral Cortex/*physiology
MH  - Efferent Pathways/physiology
MH  - Humans
RF  - 242
EDAT- 1998/03/03 00:00
MHDA- 1998/03/03 00:01
CRDT- 1998/03/03 00:00
PHST- 1998/03/03 00:00 [pubmed]
PHST- 1998/03/03 00:01 [medline]
PHST- 1998/03/03 00:00 [entrez]
AID - S0301-0082(97)00056-7 [pii]
AID - 10.1016/s0301-0082(97)00056-7 [doi]
PST - ppublish
SO  - Prog Neurobiol. 1998 Feb;54(2):149-68. doi: 10.1016/s0301-0082(97)00056-7.