PMID- 9482168
OWN - NLM
STAT- MEDLINE
DCOM- 19980327
LR  - 20190914
IS  - 0952-3278 (Print)
IS  - 0952-3278 (Linking)
VI  - 58
IP  - 1
DP  - 1998 Jan
TI  - Analysis of urinary 11-dehydrothromboxane B2 in patients with occluded retinal 
      vein using GC/SIM.
PG  - 65-8
AB  - We describe variations of 11-dehydrothromboxane B2(11-dehydro-TXB2) levels in 
      human urine samples. Retinal vein occlusion (RVO) is a thrombotic disease in 
      which the retinal vein is blocked by blood aggregations. We considered the 
      possibility that 11-dehydro-TXB2 plays an important role in the formation of RVO. 
      Thus, we determined the 11-dehydro-TXB2 levels in patients with RVO using gas 
      chromatography/selected ion monitoring (GC/SIM) and compared them with those of 
      healthy volunteers. The thromboxane levels in patients with RVO, who did not also 
      have diabetes, were significantly higher than those in healthy volunteers. One 
      cause of RVO may be the variation of thromboxane production. Furthermore, this 
      GC/SIM method can be applied to the prevention and treatment of not only RVO, but 
      also of general thrombosis.
FAU - Yamanobe, S
AU  - Yamanobe S
AD  - Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
FAU - Nakagawa, Y
AU  - Nakagawa Y
FAU - Hishinuma, T
AU  - Hishinuma T
FAU - Mizugaki, M
AU  - Mizugaki M
FAU - Tamai, M
AU  - Tamai M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Scotland
TA  - Prostaglandins Leukot Essent Fatty Acids
JT  - Prostaglandins, leukotrienes, and essential fatty acids
JID - 8802730
RN  - 54397-85-2 (Thromboxane B2)
RN  - 67910-12-7 (11-dehydro-thromboxane B2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromatography, Gas/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retinal Vein Occlusion/*etiology/pathology
MH  - Thrombosis/etiology/pathology
MH  - Thromboxane B2/*analogs & derivatives/metabolism/urine
EDAT- 1998/03/03 00:00
MHDA- 1998/03/03 00:01
CRDT- 1998/03/03 00:00
PHST- 1998/03/03 00:00 [pubmed]
PHST- 1998/03/03 00:01 [medline]
PHST- 1998/03/03 00:00 [entrez]
AID - 10.1016/s0952-3278(98)90131-4 [doi]
PST - ppublish
SO  - Prostaglandins Leukot Essent Fatty Acids. 1998 Jan;58(1):65-8. doi: 
      10.1016/s0952-3278(98)90131-4.