PMID- 9484416
OWN - NLM
STAT- MEDLINE
DCOM- 19980305
LR  - 20190514
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 50
IP  - 2 Suppl 1
DP  - 1998 Feb
TI  - Diagnostic aspects of narcolepsy.
PG  - S2-7
AB  - The diagnostic criteria for narcolepsy continue to evolve as more is learned 
      about the features of this and other sleep disorders. A variety of symptoms have 
      been said to distinguish narcolepsy from other sleep disorders, including 
      cataplexy, character of daytime sleepiness, sleep paralysis, hypnagogic 
      hallucinations, and automatic behavior. Other diagnostic assessments, such as 
      determination of human leukocyte antigen (HLA) haplotype and findings of sleep 
      laboratory assessments, also contribute to the differential diagnosis. As 
      diagnostic and analytic techniques have become more sophisticated, however, it 
      has become apparent that many of the characteristic features of 
      narcolepsy--including the HLA-DR2 haplotype, sleep-onset REM sleep, and short 
      sleep latency--may also be present in other sleep disorders. Although unambiguous 
      cataplexy does not occur with other sleep disorders and is therefore a valuable 
      symptom for diagnosis, it may occur with a few other neurologic disorders. 
      Furthermore, the clinical assessment of cataplexy-like symptoms is not always 
      straightforward. Current evidence suggests there is a fairly well-defined 
      syndrome of narcolepsy-cataplexy that is highly associated with specific HLA 
      markers and REM sleep abnormalities. On the other hand, there is substantial 
      clinical overlap between narcolepsy without cataplexy and idiopathic hypersomnia. 
      Patients with features of narcolepsy who do not have definite cataplexy and 
      patients with features of idiopathic hypersomnia must be assessed thoroughly 
      because of the possibility that other sleep disorders are the cause of the 
      symptoms.
FAU - Aldrich, M S
AU  - Aldrich MS
AD  - Department of Neurology, University of Michigan Medical Center, Ann Arbor 
      48109-0316, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Biomarkers/analysis
MH  - Diagnosis, Differential
MH  - HLA Antigens/analysis
MH  - Haplotypes
MH  - Humans
MH  - Narcolepsy/*diagnosis
MH  - Polysomnography
MH  - Reproducibility of Results
MH  - Sleep Wake Disorders/diagnosis
RF  - 26
EDAT- 1998/03/04 00:00
MHDA- 1998/03/04 00:01
CRDT- 1998/03/04 00:00
PHST- 1998/03/04 00:00 [pubmed]
PHST- 1998/03/04 00:01 [medline]
PHST- 1998/03/04 00:00 [entrez]
AID - 10.1212/wnl.50.2_suppl_1.s2 [doi]
PST - ppublish
SO  - Neurology. 1998 Feb;50(2 Suppl 1):S2-7. doi: 10.1212/wnl.50.2_suppl_1.s2.