PMID- 9484662 OWN - NLM STAT- MEDLINE DCOM- 19980319 LR - 20191114 IS - 0887-8013 (Print) IS - 1098-2825 (Electronic) IS - 0887-8013 (Linking) VI - 12 IP - 1 DP - 1998 TI - Urinary levels of monocyte chemoattractant protein (MCP)-1 and disease activity in patients with IgA nephropathy. PG - 1-5 AB - Using a quantitative sandwich ELISA, we studied 17 patients with IgA nephropathy to determine if levels of urinary monocyte chemoattractant protein-1 (MCP-1) might reflect the disease activity. The levels of urinary MCP-1 in patients with the advanced stage were significantly higher than those in patients with the mild stage of the disease, or in healthy controls. The results showed a significant correlation between the levels of urinary MCP-1 and the disease activity, i.e., levels of urinary casts and urinary protein. It was thus suggested that the measurement of urinary MCP-1 is useful in evaluating the degree of renal injuries and/or prognosis in patients with IgA nephropathy. FAU - Saitoh, A AU - Saitoh A AD - Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan. FAU - Suzuki, Y AU - Suzuki Y FAU - Takeda, M AU - Takeda M FAU - Kubota, K AU - Kubota K FAU - Itoh, K AU - Itoh K FAU - Tomino, Y AU - Tomino Y LA - eng PT - Journal Article PL - United States TA - J Clin Lab Anal JT - Journal of clinical laboratory analysis JID - 8801384 RN - 0 (Chemokine CCL2) SB - IM MH - Adult MH - Chemokine CCL2/urine MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Glomerulonephritis, IGA/*urine MH - Humans MH - Male MH - Middle Aged PMC - PMC6808122 EDAT- 1998/03/04 03:04 MHDA- 2000/06/20 09:00 PMCR- 1998/12/07 CRDT- 1998/03/04 03:04 PHST- 1998/03/04 03:04 [pubmed] PHST- 2000/06/20 09:00 [medline] PHST- 1998/03/04 03:04 [entrez] PHST- 1998/12/07 00:00 [pmc-release] AID - 10.1002/(SICI)1098-2825(1998)12:1<1::AID-JCLA1>3.0.CO;2-F [pii] AID - JCLA1 [pii] AID - 10.1002/(sici)1098-2825(1998)12:1<1::aid-jcla1>3.0.co;2-f [doi] PST - ppublish SO - J Clin Lab Anal. 1998;12(1):1-5. doi: 10.1002/(sici)1098-2825(1998)12:1<1::aid-jcla1>3.0.co;2-f.