PMID- 9484786
OWN - NLM
STAT- MEDLINE
DCOM- 19980313
LR  - 20100526
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 16
IP  - 7
DP  - 1998 Feb 19
TI  - t(6;8), t(8;9) and t(8;13) translocations associated with stem cell 
      myeloproliferative disorders have close or identical breakpoints in chromosome 
      region 8p11-12.
PG  - 945-9
AB  - A stem-cell myeloproliferative disorder involving T- and B-cell, and myeloid 
      lineages, is associated with three different translocations with a breakpoint in 
      region p11-12 of chromosome 8: t(6;8)(q27;p11), t(8;9)(p11;q33), and 
      t(8;13)(p12;q12), respectively. Using fluorescence in situ hybridization (FISH), 
      we have analysed blood cells from a series of five patients carrying these 
      different translocations. We have identified cosmids from chromosome region 
      8p11-12 that span the breakpoint in all the cases. They are specific for the 
      FCFR1 gene that encodes a receptor for members of the FGF family. The breakpoint 
      was further detected by Southern and pulsed-field gel electrophoresis analyses 
      with probes from the FGFR1 locus.
FAU - Chaffanet, M
AU  - Chaffanet M
AD  - Laboratoire d'Oncologie Moleculaire, U.119 INSERM, Institut de Cancerologie et 
      d'Immunologie de Marseille, France.
FAU - Popovici, C
AU  - Popovici C
FAU - Leroux, D
AU  - Leroux D
FAU - Jacrot, M
AU  - Jacrot M
FAU - Adelaide, J
AU  - Adelaide J
FAU - Dastugue, N
AU  - Dastugue N
FAU - Gregoire, M J
AU  - Gregoire MJ
FAU - Hagemeijer, A
AU  - Hagemeijer A
FAU - Lafage-Pochitaloff, M
AU  - Lafage-Pochitaloff M
FAU - Birnbaum, D
AU  - Birnbaum D
FAU - Pebusque, M J
AU  - Pebusque MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Receptors, Fibroblast Growth Factor)
RN  - EC 2.7.10.1 (FGFR1 protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 13
MH  - Chromosomes, Human, Pair 6
MH  - *Chromosomes, Human, Pair 8
MH  - Chromosomes, Human, Pair 9
MH  - Female
MH  - Genes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Myeloproliferative Disorders/*genetics/pathology
MH  - *Receptor Protein-Tyrosine Kinases
MH  - Receptor, Fibroblast Growth Factor, Type 1
MH  - Receptors, Fibroblast Growth Factor/*genetics
MH  - Restriction Mapping
MH  - Translocation, Genetic
EDAT- 1998/03/04 00:00
MHDA- 1998/03/04 00:01
CRDT- 1998/03/04 00:00
PHST- 1998/03/04 00:00 [pubmed]
PHST- 1998/03/04 00:01 [medline]
PHST- 1998/03/04 00:00 [entrez]
AID - 10.1038/sj.onc.1201601 [doi]
PST - ppublish
SO  - Oncogene. 1998 Feb 19;16(7):945-9. doi: 10.1038/sj.onc.1201601.