PMID- 9486769
OWN - NLM
STAT- MEDLINE
DCOM- 19980331
LR  - 20161124
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 51
IP  - 3
DP  - 1998 Feb 1
TI  - Seizures and neuronal damage induced in the rat by activation of group I 
      metabotropic glutamate receptors with their selective agonist 
      3,5-dihydroxyphenylglycine.
PG  - 339-48
AB  - While it is well documented that the overactivation of ionotropic glutamate 
      receptors leads to seizures and excitotoxic injury, little is known about the 
      role of metabotropic glutamate receptors (mGluRs) in epileptogenesis and neuronal 
      injury. Intracerebroventricular (i.c.v.) infusion of the group I mGluR specific 
      agonist (R,S)-3,5-dihydroxyphenylglycine (3,5-DHPG) (1.5 micromol) to conscious 
      rats produced severe and delayed seizures (onset at 4 hr) in 70% of the animals. 
      The i.c.v. infusion of the group I mGluR non-selective agonist 
      1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) (2 micromol) 
      produced a similar rate of severe seizures, but with an early onset (0.6 hr). The 
      analysis of motor activity showed that 3,5-DHPG elicited higher central 
      stimulatory action than did 1S,3R-ACPD. Histopathological analysis of the 
      hippocampus showed that 3,5-DHPG produced severe neuronal damage mainly in the 
      CA1 pyramidal neurons and, to a lesser extent, in the CA3. Although 1S,3R-ACPD 
      infusion also induced a slight injury of the CA1 and CA3 pyramidal neurons, 
      damage was greater in the CA4 and dentate gyrus cells. In conclusion, the in vivo 
      activation of group I mGluRs with the selective agonist 3,5-DHPG produces 
      hyperexcitatory effects that lead to seizures and neuronal damage, these effects 
      being more severe than those observed after infusion of the non-selective agonist 
      1S,3R-ACPD.
FAU - Camon, L
AU  - Camon L
AD  - Department of Pharmacology and Toxicology, Institut d'Investigacions Biomediques 
      de Barcelona, Cosejo Superior de Investigaciones Cientificas, Spain. 
      lcsfat@cid.csic.es
FAU - Vives, P
AU  - Vives P
FAU - de Vera, N
AU  - de Vera N
FAU - Martinez, E
AU  - Martinez E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (Resorcinols)
RN  - 0TQU7668EI (Cycloleucine)
RN  - 111900-32-4 (1-amino-1,3-dicarboxycyclopentane)
RN  - 5YR2N37E6D (3,5-dihydroxyphenylglycine)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Cerebral Ventricles
MH  - Cycloleucine/analogs & derivatives/pharmacology
MH  - Excitatory Amino Acid Agonists/*pharmacology
MH  - Glycine/*analogs & derivatives/pharmacology
MH  - Infusions, Parenteral
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neurons/*drug effects
MH  - Neuroprotective Agents/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Metabotropic Glutamate/*agonists
MH  - Resorcinols/*pharmacology
MH  - Seizures/*chemically induced
EDAT- 1998/03/05 03:04
MHDA- 2000/06/20 09:00
CRDT- 1998/03/05 03:04
PHST- 1998/03/05 03:04 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/03/05 03:04 [entrez]
AID - 10.1002/(SICI)1097-4547(19980201)51:3<339::AID-JNR7>3.0.CO;2-H [pii]
AID - 10.1002/(SICI)1097-4547(19980201)51:3<339::AID-JNR7>3.0.CO;2-H [doi]
PST - ppublish
SO  - J Neurosci Res. 1998 Feb 1;51(3):339-48. doi: 
      10.1002/(SICI)1097-4547(19980201)51:3<339::AID-JNR7>3.0.CO;2-H.