PMID- 9488359
OWN - NLM
STAT- MEDLINE
DCOM- 19980305
LR  - 20061115
IS  - 0022-3395 (Print)
IS  - 0022-3395 (Linking)
VI  - 84
IP  - 1
DP  - 1998 Feb
TI  - Schistosoma mansoni infection in IgE-producing and IgE-deficient mice.
PG  - 171-4
AB  - The immunoglobulin E (IgE) response, a hallmark of helminthic infection, is 
      generally considered a major host defense against schistosomiasis mansoni. In 
      support, it was reported that mice with a null mutation of the Ce gene, which are 
      thus incapable of making IgE, developed Schistosoma mansoni worm burdens 2-fold 
      greater than wild-type mice. However, in another study, reduction of the IgE 
      response in mice to a primary S. mansoni infection by anti-IgE treatment resulted 
      in decreased worm burden and fecundity, suggesting that IgE plays a detrimental, 
      rather than beneficial, role for the host in schistosomiasis. In a third study, 
      S. mansoni worm burden and egg production in normal and in IL-4-deficient mice 
      that produce negligible IgE levels did not differ significantly, and it appeared 
      that IgE did not affect parasite survival or fecundity. In an attempt to resolve 
      these controversies, we examined hepatic worm load and egg production in the 
      liver and small intestine of IgE-deficient (SJA/9) and control IgE-producing 
      (SJL/J) mice, 8 wk after S. mansoni infection. No differences were observed in 
      worm burden, total egg production, and number of eggs produced per female worm in 
      the 2 mouse strains, confirming the data that imply that IgE does not play an 
      essential role in primary S. mansoni infection.
FAU - El Ridi, R
AU  - El Ridi R
AD  - Department of Parasitology, Hirosaki University School of Medicine, Aomori, 
      Japan.
FAU - Ozaki, T
AU  - Ozaki T
FAU - Kamiya, H
AU  - Kamiya H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Parasitol
JT  - The Journal of parasitology
JID - 7803124
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Dysgammaglobulinemia/complications/*immunology
MH  - Female
MH  - Immunoglobulin E/*biosynthesis/*deficiency/physiology
MH  - Male
MH  - Mice
MH  - Oviposition/immunology
MH  - Schistosoma mansoni/*immunology/physiology
MH  - Schistosomiasis mansoni/complications/*immunology
EDAT- 1998/03/06 00:00
MHDA- 1998/03/06 00:01
CRDT- 1998/03/06 00:00
PHST- 1998/03/06 00:00 [pubmed]
PHST- 1998/03/06 00:01 [medline]
PHST- 1998/03/06 00:00 [entrez]
PST - ppublish
SO  - J Parasitol. 1998 Feb;84(1):171-4.