PMID- 9489421
OWN - NLM
STAT- MEDLINE
DCOM- 19980423
LR  - 20181201
IS  - 0867-7077 (Print)
IS  - 0867-7077 (Linking)
VI  - 65
IP  - 3-4
DP  - 1997
TI  - [Theophylline does not exert an effect on the early phase of TNF-alpha through 
      the activity of human monocytes].
PG  - 239-43
AB  - Tumor necrosis factor-alpha (TNF-alpha) is commonly recognized as a one of the 
      most important mediators of allergic inflammation and hyperreactivity in 
      bronchial asthma. Several studies proved the inhibitory effect of theophylline 
      (including it's subtherapeutic doses) on the synthesis of TNF-alpha in 24 hrs 
      monocyte cultures. The aim of our study was to determine the influence of 
      therapeutic and subtherapeutic concentrations of the drug on the early phase of 
      TNF-alpha release. We showed that theophylline did not significantly alter the 
      cytokine concentration measured by Elisa method in supernatants from 2 hrs 
      monocyte cultures stimulated by LPS (1 microgram/ml). Therefore, we concluded 
      that the mechanism of theophylline inhibitory action on TNF-alpha production is 
      more likely associated with changes in genome expression, than with the 
      inhibition of the cytokine liberation from the cell.
FAU - Chorostowska-Wynimko, J
AU  - Chorostowska-Wynimko J
AD  - Zakladu Immunologii, Instytutu Gruzlicy i Chorob Pluc w Warszawie.
FAU - Demkow, U
AU  - Demkow U
FAU - Kus, J
AU  - Kus J
FAU - Skopinska-Rozewska, E
AU  - Skopinska-Rozewska E
LA  - pol
PT  - Journal Article
TT  - Teofilina nie wplywa na wczesna faze uwalniania TNF-alpha przez aktywowane 
      monocyty ludzkie.
PL  - Poland
TA  - Pneumonol Alergol Pol
JT  - Pneumonologia i alergologia polska
JID - 9302892
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - C137DTR5RG (Theophylline)
SB  - IM
MH  - Humans
MH  - In Vitro Techniques
MH  - Monocytes/*drug effects/metabolism
MH  - Reference Values
MH  - Theophylline/*pharmacology
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/*drug effects/metabolism
EDAT- 1997/01/01 00:00
MHDA- 1998/03/07 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/03/07 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PST - ppublish
SO  - Pneumonol Alergol Pol. 1997;65(3-4):239-43.