PMID- 9493081
OWN - NLM
STAT- MEDLINE
DCOM- 19980403
LR  - 20221207
IS  - 0022-0302 (Print)
IS  - 0022-0302 (Linking)
VI  - 81
IP  - 1
DP  - 1998 Jan
TI  - The effect of oral feeding of Lactobacillus casei strain Shirota on 
      immunoglobulin E production in mice.
PG  - 48-53
AB  - We investigated the effect of oral feeding of heat-killed Lactobacillus casei 
      strain Shirota on immunoglobulin E (IgE) production in mice. The strain was 
      orally administered to BALB/c mice that had been preinjected intraperitoneally 
      with ovalbumin, and the level of IgE in serum was determined. Results indicated 
      that the oral feeding of L. casei strain Shirota was effective in inhibiting IgE 
      production in serum, and the IgE production in response to ovalbumin was 
      significantly inhibited in the mice. The in vitro production of IgE by the spleen 
      cells from mice fed L. casei strain Shirota in response to restimulation with 
      ovalbumin was inhibited in contrast to that of spleen cells from the control 
      group. We also examined the pattern of cytokine production by spleen cells from 
      mice fed L. casei strain Shirota followed by restimulation with ovalbumin in 
      vitro. In the mice fed L. casei strain Shirota, the production by the spleen 
      cells of Th1 cell-associated cytokines, such as interferon-gamma and 
      interleukin-2, was higher than that by the spleen cells from the control group. 
      In contrast, the production of Th2 cell-associated cytokines, such as 
      interleukin-4, interleukin-5, interleukin-6, and interleukin-10, by spleen cells 
      in the group fed L. casei strain Shirota was lower than that by the cells from 
      the control group. Furthermore, the interleukin-12 production of the spleen cells 
      from mice fed L. casei strain Shirota was also higher than that of the control 
      group.
FAU - Matsuzaki, T
AU  - Matsuzaki T
AD  - Yakult Central Institute for Microbiological Research, Tokyo, Japan.
FAU - Yamazaki, R
AU  - Yamazaki R
FAU - Hashimoto, S
AU  - Hashimoto S
FAU - Yokokura, T
AU  - Yokokura T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukins)
RN  - 187348-17-0 (Interleukin-12)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Hot Temperature
MH  - Immunoglobulin E/*biosynthesis
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-12/biosynthesis
MH  - Interleukin-2/biosynthesis
MH  - Interleukins/biosynthesis
MH  - *Lacticaseibacillus casei
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - *Probiotics
MH  - Rats
MH  - Rats, Wistar
MH  - Spleen/immunology
EDAT- 1998/03/11 00:00
MHDA- 1998/03/11 00:01
CRDT- 1998/03/11 00:00
PHST- 1998/03/11 00:00 [pubmed]
PHST- 1998/03/11 00:01 [medline]
PHST- 1998/03/11 00:00 [entrez]
AID - S0022-0302(98)75549-3 [pii]
AID - 10.3168/jds.S0022-0302(98)75549-3 [doi]
PST - ppublish
SO  - J Dairy Sci. 1998 Jan;81(1):48-53. doi: 10.3168/jds.S0022-0302(98)75549-3.