PMID- 9493658
OWN - NLM
STAT- MEDLINE
DCOM- 19980423
LR  - 20220410
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 10
IP  - 12
DP  - 1997 Dec
TI  - Investigations on the renin-angiotensin system in acute severe asthma.
PG  - 2766-71
AB  - The renin-angiotensin system is activated in acute severe asthma. The precise 
      mechanism of activation is at present unknown, but may involve, beta2-agonists, 
      catecholamines or proteases released in airway inflammation. This study aims to 
      identify potential factors involved in the activation of the renin-angiotensin 
      system in acute asthma. Forty asthmatics with severe exacerbations of asthma, 
      assessed by measurement of peak expiratory flow rate (mean (SD) 35 (18)% 
      predicted), oxygen saturation (94 (4)%) and pulse rate (108 (16) beats x min(-1)) 
      were recruited. Nineteen (48%) asthmatics had elevated plasma angiotensin II 
      levels (median (interquartile range) 10.9 (4.3-23.5) pg x mL(-1) (normal range 
      3-12 pg x mL(-1))) and 10 (25%) had elevated plasma renin concentration (22.0 
      (10.0-50.0) microU x mL(-1) (normal range 9-50 microU x mL(-1))). Plasma renin 
      and angiotensin II correlated strongly, implying renin-dependent angiotensin II 
      formation. No correlation was found between plasma salbutamol, adrenaline, 
      nor-adrenaline, endothelin-1, histamine, eosinophilic cationic protein, serum 
      angio-tensin-converting enzyme (ACE) activity, total immunoglobulin E (IgE), urea 
      and electrolytes, indicators of the severity of the attack, atopic status, blood 
      pressure and renin or angiotensin II levels. We conclude that although a 
      subpopulation of asthmatics appear to have raised renin and angiotensin II during 
      attacks of acute, severe asthma, the mechanism of activation of the 
      renin-angiotensin system remains unclear.
FAU - Ramsay, S G
AU  - Ramsay SG
AD  - Dept of Respiratory Medicine, Western Infirmary, Glasgow, Scotland, UK.
FAU - Dagg, K D
AU  - Dagg KD
FAU - McKay, I C
AU  - McKay IC
FAU - Lipworth, B J
AU  - Lipworth BJ
FAU - McSharry, C
AU  - McSharry C
FAU - Thomson, N C
AU  - Thomson NC
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Catecholamines)
RN  - 0 (Endothelin-1)
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Angiotensin II/*blood
MH  - Asthma/blood/enzymology/*physiopathology
MH  - Catecholamines/blood
MH  - Endothelin-1/blood
MH  - Female
MH  - Forced Expiratory Volume
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption
MH  - Peak Expiratory Flow Rate
MH  - Peptidyl-Dipeptidase A/*metabolism
MH  - Renin/*blood
MH  - *Renin-Angiotensin System
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 1998/03/11 00:00
MHDA- 1998/03/11 00:01
CRDT- 1998/03/11 00:00
PHST- 1998/03/11 00:00 [pubmed]
PHST- 1998/03/11 00:01 [medline]
PHST- 1998/03/11 00:00 [entrez]
AID - 10.1183/09031936.97.10122766 [doi]
PST - ppublish
SO  - Eur Respir J. 1997 Dec;10(12):2766-71. doi: 10.1183/09031936.97.10122766.