PMID- 9493787
OWN - NLM
STAT- MEDLINE
DCOM- 19980421
LR  - 20141120
IS  - 0254-9670 (Print)
IS  - 0254-9670 (Linking)
VI  - 14
IP  - 3
DP  - 1997
TI  - Analysis of FcgammaRII gene polymorphisms in Wegener's granulomatosis.
PG  - 183-95
AB  - Fcgamma receptors (FcgammaRs) are potent initiators of proinflammatory reactions 
      and tissue injury programs through the oxidative burst, degranulation and the 
      production of a variety of proinflammatory cytokines. Direct experimental 
      evidence indicates that translocation of ANCA target from intracellular granules 
      to the neutrophil membrane and subsequent binding of ANCA enables 
      FcgammaR-mediated neutrophil activation. In the presence of ANCA, these data 
      provide a framework from which to understand the importance of ANCA class, 
      subclass, and titer in Wegener's granulomatosis and other ANCA-positive 
      vasculitides. The well-characterized and functionally important alleles of 
      neutrophil FcgammaR (FcgammaRIIa-H131/R131 and FcgammaRIIIb-NA1/NA2) are possible 
      inheritable genetic elements that may alter disease severity and/or phenotype.
FAU - Edberg, J C
AU  - Edberg JC
AD  - Division of Clinical Immunology and Rheumatology, University of Alabama at 
      Birmingham, 35294-0006, USA.
FAU - Wainstein, E
AU  - Wainstein E
FAU - Wu, J
AU  - Wu J
FAU - Csernok, E
AU  - Csernok E
FAU - Sneller, M C
AU  - Sneller MC
FAU - Hoffman, G S
AU  - Hoffman GS
FAU - Keystone, E C
AU  - Keystone EC
FAU - Gross, W L
AU  - Gross WL
FAU - Kimberly, R P
AU  - Kimberly RP
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Exp Clin Immunogenet
JT  - Experimental and clinical immunogenetics
JID - 8411714
RN  - 0 (Antigens, CD)
RN  - 0 (Fc gamma receptor IIA)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Alleles
MH  - Antigens, CD/*genetics/immunology
MH  - Granulomatosis with Polyangiitis/*genetics/immunology
MH  - Humans
MH  - Immunoglobulin G/immunology
MH  - *Polymorphism, Genetic
MH  - Receptors, IgG/*genetics/immunology
EDAT- 1997/01/01 00:00
MHDA- 1998/03/11 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1998/03/11 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PST - ppublish
SO  - Exp Clin Immunogenet. 1997;14(3):183-95.