PMID- 9499081
OWN - NLM
STAT- MEDLINE
DCOM- 19980312
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 72
IP  - 3
DP  - 1998 Mar
TI  - A 2.9-kilobase noncoding nuclear RNA functions in the establishment of persistent 
      Hz-1 viral infection.
PG  - 2233-45
AB  - Differential viral gene expression during both productive and persistent 
      infections of Hz-1 virus in insect cells was elucidated. Despite more than 100 
      viral transcripts being expressed during productive viral infection, massive 
      viral gene shutoff was observed during viral persistency, leaving the 2.9-kb 
      persistence-associated transcript 1 (PAT1) as the only detectable viral RNA. 
      Persistence-associated gene 1 (pag1), which encodes PAT1, was cloned and found to 
      contain no significant open reading frames. PAT1 is not associated with the 
      cellular translation machinery and is located exclusively in the nucleus. Further 
      experiments showed that PAT1 is functional in the establishment of persistent 
      Hz-1 viral infection in the cells. All the evidence collectively indicates that 
      PAT1 is a novel nuclear transcript of viral origin. Our results showed that 
      although PAT1 and XIST RNA, a mammalian X-inactive specific transcript, are 
      transcribed by different genes, they have interesting similarities.
FAU - Chao, Y C
AU  - Chao YC
AD  - Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, Taiwan, 
      Republic of China. mbycchao@ccvax.sinica.edu.tw
FAU - Lee, S T
AU  - Lee ST
FAU - Chang, M C
AU  - Chang MC
FAU - Chen, H H
AU  - Chen HH
FAU - Chen, S S
AU  - Chen SS
FAU - Wu, T Y
AU  - Wu TY
FAU - Liu, F H
AU  - Liu FH
FAU - Hsu, E L
AU  - Hsu EL
FAU - Hou, R F
AU  - Hou RF
LA  - eng
SI  - GENBANK/U03488
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA, Viral)
RN  - 0 (Pag1 protein, Heliothis zea virus 1)
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Animals
MH  - Baculoviridae/*genetics/physiology
MH  - Base Sequence
MH  - Binding Sites
MH  - Cell Line
MH  - Cell Nucleus/metabolism
MH  - DNA, Viral
MH  - *Genes, Viral
MH  - Genome, Viral
MH  - Molecular Sequence Data
MH  - Moths/cytology
MH  - Multigene Family
MH  - Open Reading Frames
MH  - Peptide Chain Initiation, Translational
MH  - Promoter Regions, Genetic
MH  - *RNA, Viral
MH  - Repetitive Sequences, Nucleic Acid
MH  - Ribosomes
MH  - Spodoptera/cytology
MH  - Transcription, Genetic
MH  - Viral Proteins/*genetics
MH  - *Virus Latency
PMC - PMC109520
EDAT- 1998/03/14 00:00
MHDA- 1998/03/14 00:01
PMCR- 1998/03/01
CRDT- 1998/03/14 00:00
PHST- 1998/03/14 00:00 [pubmed]
PHST- 1998/03/14 00:01 [medline]
PHST- 1998/03/14 00:00 [entrez]
PHST- 1998/03/01 00:00 [pmc-release]
AID - 1073 [pii]
AID - 10.1128/JVI.72.3.2233-2245.1998 [doi]
PST - ppublish
SO  - J Virol. 1998 Mar;72(3):2233-45. doi: 10.1128/JVI.72.3.2233-2245.1998.