PMID- 9500701
OWN - NLM
STAT- MEDLINE
DCOM- 19980319
LR  - 20061115
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 27
IP  - 3
DP  - 1998 Mar
TI  - Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion 
      molecule-1 following ischemia-reperfusion of the liver in rats.
PG  - 727-34
AB  - Intercellular adhesion molecule-1 (ICAM-1) is important in neutrophil-dependent 
      injury. We investigated the effects of monocyte chemoattractant protein-1 (MCP-1) 
      produced by Kupffer cells on ICAM-1 expression after ischemia-reperfusion in rat 
      liver by occluding the portal vein for 30 minutes. Serum concentrations of MCP-1 
      increased persistently. By Northern analysis, MCP-1 mRNA increased early and 
      persisted. Kupffer cells harvested 6 hours after reperfusion also expressed this 
      transcript. The transcript and protein also were produced by Kupffer cells from 
      naive controls in response to reactive oxygen species. ICAM-1 mRNA transcripts 
      increased, peaked 3 hours after reperfusion, and decreased gradually thereafter. 
      The level of ICAM-1 mRNA transcripts in the WK-5 rat endothelial cell line were 
      markedly enhanced by MCP-1. These results suggest that MCP-1 released by Kupffer 
      cells early after ischemia-reperfusion modulates neutrophil-dependent tissue 
      injury via ICAM-1.
FAU - Yamaguchi, Y
AU  - Yamaguchi Y
AD  - Department of Surgery II, Kumamoto University Medical School, Japan.
FAU - Matsumura, F
AU  - Matsumura F
FAU - Takeya, M
AU  - Takeya M
FAU - Ichiguchi, O
AU  - Ichiguchi O
FAU - Kuratsu, J I
AU  - Kuratsu JI
FAU - Horiuchi, T
AU  - Horiuchi T
FAU - Akizuki, E
AU  - Akizuki E
FAU - Matsuda, T
AU  - Matsuda T
FAU - Okabe, K
AU  - Okabe K
FAU - Ohshiro, H
AU  - Ohshiro H
FAU - Liang, J
AU  - Liang J
FAU - Mori, K
AU  - Mori K
FAU - Yamada, S
AU  - Yamada S
FAU - Takahashi, K
AU  - Takahashi K
FAU - Ogawa, M
AU  - Ogawa M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Chemokine CCL2/*physiology
MH  - Intercellular Adhesion Molecule-1/*biosynthesis/genetics
MH  - Ischemia/*metabolism
MH  - Liver/*blood supply
MH  - Male
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion
EDAT- 1998/03/21 00:00
MHDA- 1998/03/21 00:01
CRDT- 1998/03/21 00:00
PHST- 1998/03/21 00:00 [pubmed]
PHST- 1998/03/21 00:01 [medline]
PHST- 1998/03/21 00:00 [entrez]
AID - S0270913998001086 [pii]
AID - 10.1002/hep.510270314 [doi]
PST - ppublish
SO  - Hepatology. 1998 Mar;27(3):727-34. doi: 10.1002/hep.510270314.