PMID- 9501225
OWN - NLM
STAT- MEDLINE
DCOM- 19980410
LR  - 20220408
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 95
IP  - 6
DP  - 1998 Mar 17
TI  - Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated 
      astrocytes and elevation in AIDS dementia.
PG  - 3117-21
AB  - Activated monocytes release a number of substances, including inflammatory 
      cytokines and eicosanoids, that are highly toxic to cells of the central nervous 
      system. Because monocytic infiltration of the central nervous system closely 
      correlates with HIV-1-associated dementia, it has been suggested that 
      monocyte-derived toxins mediate nervous system damage. In the present study, we 
      show that the HIV-1 transactivator protein Tat significantly increases astrocytic 
      expression and release of monocyte chemoattractant protein-1 (MCP-1). Astrocytic 
      release of beta-chemokines, which are relatively less selective for monocytes, 
      including RANTES, macrophage inflammatory protein-1alpha, and macrophage 
      inflammatory protein-1beta, was not observed. We also show that MCP-1 is 
      expressed in the brains of patients with HIV-1-associated dementia and that, of 
      the beta-chemokines tested, only MCP-1 could be detected in the cerebrospinal 
      fluid of patients with this condition. Together, these data provide a potential 
      link between the presence of HIV-1 in the brain and the monocytic infiltration 
      that may substantially contribute to dementia.
FAU - Conant, K
AU  - Conant K
AD  - Laboratory of Molecular Medicine and Neuroscience, National Institute of 
      Neurological Disorders and Stroke, Building 36, Room 5W21, National Institutes of 
      Health, Bethesda, MD 20892, USA. conant@codon.nih.gov
FAU - Garzino-Demo, A
AU  - Garzino-Demo A
FAU - Nath, A
AU  - Nath A
FAU - McArthur, J C
AU  - McArthur JC
FAU - Halliday, W
AU  - Halliday W
FAU - Power, C
AU  - Power C
FAU - Gallo, R C
AU  - Gallo RC
FAU - Major, E O
AU  - Major EO
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Gene Products, tat)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (tat Gene Products, Human Immunodeficiency Virus)
SB  - IM
MH  - AIDS Dementia Complex/blood/cerebrospinal fluid/etiology/*metabolism
MH  - Adult
MH  - Astrocytes/*drug effects
MH  - Brain/metabolism
MH  - Cells, Cultured
MH  - Chemokine CCL2/*biosynthesis/blood/cerebrospinal fluid
MH  - Chemokine CCL4
MH  - Chemokine CCL5/analysis
MH  - Gene Products, tat/*pharmacology
MH  - *HIV-1
MH  - Humans
MH  - Macrophage Inflammatory Proteins/analysis
MH  - Middle Aged
MH  - Monocytes
MH  - Prospective Studies
MH  - tat Gene Products, Human Immunodeficiency Virus
PMC - PMC19704
EDAT- 1998/04/18 00:00
MHDA- 1998/04/18 00:01
PMCR- 1998/09/17
CRDT- 1998/04/18 00:00
PHST- 1998/04/18 00:00 [pubmed]
PHST- 1998/04/18 00:01 [medline]
PHST- 1998/04/18 00:00 [entrez]
PHST- 1998/09/17 00:00 [pmc-release]
AID - 0044 [pii]
AID - 10.1073/pnas.95.6.3117 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3117-21. doi: 10.1073/pnas.95.6.3117.