PMID- 9507236
OWN - NLM
STAT- MEDLINE
DCOM- 19980414
LR  - 20190814
IS  - 0024-4201 (Print)
IS  - 0024-4201 (Linking)
VI  - 33
IP  - 2
DP  - 1998 Feb
TI  - Low-fat, monounsaturate-rich diets reduce susceptibility of low density 
      lipoproteins to peroxidation ex vivo.
PG  - 149-57
AB  - Oxidative modification of low density lipoprotein (LDL) plays an important role 
      in the process of atherosclerosis. The susceptibility of LDL to oxidation and the 
      amount of peroxidation products formed are influenced by the lipoprotein content 
      of 18:1n-9, 18:2n-6, and the 18:2n-6/18:1n-9 ratio, which is dependent in part on 
      dietary fatty acids. The purpose of this study was to determine if changing from 
      a typical American diet to a low-fat, monounsaturate-rich diet (LFMR) would 
      result in favorable alterations in the fatty acid composition and oxidative 
      profile of LDL in hypercholesterolemic individuals. Free-living postmenopausal 
      hypercholesterolemic women who routinely consumed a diet moderately high in total 
      fat and total saturates (34 and 11%, respectively) followed an LFMR diet (26% 
      fat, 6% saturated fat, and 14% monounsaturated fat) for 6 mon. Sixteen 
      postmenopausal hypercholesterolemic women already following standard low-fat (LF) 
      diets acted as a control for seasonal variations in serum lipids. LDL from 
      randomly selected subjects (LF n = 6, LFMR n = 5) was evaluated. LFMR diets 
      resulted in LDL with increased concentrations and percentages of 18:1n-9, reduced 
      18:2n-6/18:1n-9 ratio, and lower percentages of 18:2n-6. No significant changes 
      in LDL fatty acids occurred in the LF group. Conjugated diene lag time increased 
      in both groups during copper-induced in vitro oxidation. Only the LFMR group 
      experienced an increase in lipid peroxide lag time and a decrease in lipid 
      peroxide formation. The LFMR diet was well tolerated and may be of therapeutic 
      value in the treatment of hypercholesterolemia.
FAU - O'Bryne, D J
AU  - O'Bryne DJ
AD  - Department of Food Science and Human Nutrition, University of Florida, 
      Gainesville 32611, USA.
FAU - O'Keefe, S F
AU  - O'Keefe SF
FAU - Shireman, R B
AU  - Shireman RB
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Lipoproteins, LDL)
SB  - IM
MH  - Aged
MH  - Dietary Fats, Unsaturated/*therapeutic use
MH  - Female
MH  - Humans
MH  - Hypercholesterolemia/*diet therapy
MH  - Lipid Peroxidation/*drug effects
MH  - Lipoproteins, LDL/*metabolism
MH  - Middle Aged
MH  - Postmenopause/*physiology
EDAT- 1998/03/21 00:00
MHDA- 1998/03/21 00:01
CRDT- 1998/03/21 00:00
PHST- 1998/03/21 00:00 [pubmed]
PHST- 1998/03/21 00:01 [medline]
PHST- 1998/03/21 00:00 [entrez]
AID - 10.1007/s11745-998-0190-1 [doi]
PST - ppublish
SO  - Lipids. 1998 Feb;33(2):149-57. doi: 10.1007/s11745-998-0190-1.