PMID- 9508673
OWN - NLM
STAT- MEDLINE
DCOM- 19980317
LR  - 20190921
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 36
IP  - 6
DP  - 1997 Dec
TI  - Antianaphylactic properties of eugenol.
PG  - 475-80
AB  - The effects of eugenol, a major component of clove, on anaphylaxis were evaluated 
      in rats. Eugenol inhibited compound 48/80-induced systemic anaphylaxis 100% with 
      a dose of 10 micrograms g-1 body weight (BW). While serum levels of histamine 
      were markedly elevated after compound 48/80 injection in all groups of rats, rats 
      injected with eugenol showed a significant reduction in serum histamine levels. 
      Eugenol also inhibited passive cutaneous anaphylaxis activated by 
      anti-dinitrophenyl (DNP) IgE. Eugenol dose-dependently inhibited histamine 
      release from the rat peritoneal mast cells (RPMC) activated by compound 48/80 or 
      anti-DNP IgE. The morphological examination clearly showed that eugenol prevented 
      the anaphylactic degranulation of RPMC. Moreover, Eugenol (10 micrograms ml-1) 
      had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis 
      factor-alpha production. These results suggest that eugenol has antianaphylactic 
      properties by preventing mast cell degranulation.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, Wonkwang University, Iksan, Chonbuk, South 
      Korea.
FAU - Lee, E H
AU  - Lee EH
FAU - Kim, C Y
AU  - Kim CY
FAU - Chung, J G
AU  - Chung JG
FAU - Kim, S H
AU  - Kim SH
FAU - Lim, J P
AU  - Lim JP
FAU - Shin, T Y
AU  - Shin TY
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Dinitrophenols)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3T8H1794QW (Eugenol)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 45PG892GO1 (Evans Blue)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Anaphylaxis/chemically induced/*drug therapy
MH  - Animals
MH  - Cell Degranulation/drug effects
MH  - Dinitrophenols/immunology
MH  - Eugenol/*pharmacology/*therapeutic use
MH  - Evans Blue
MH  - Histamine/blood
MH  - Immunoglobulin E/pharmacology
MH  - In Vitro Techniques
MH  - Macrophages, Peritoneal/cytology/drug effects/immunology
MH  - Mast Cells/cytology/drug effects/metabolism
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 1998/03/21 00:00
MHDA- 1998/03/21 00:01
CRDT- 1998/03/21 00:00
PHST- 1998/03/21 00:00 [pubmed]
PHST- 1998/03/21 00:01 [medline]
PHST- 1998/03/21 00:00 [entrez]
AID - S1043661897902565 [pii]
AID - 10.1006/phrs.1997.0256 [doi]
PST - ppublish
SO  - Pharmacol Res. 1997 Dec;36(6):475-80. doi: 10.1006/phrs.1997.0256.