PMID- 9509902
OWN - NLM
STAT- MEDLINE
DCOM- 19980402
LR  - 20220331
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 38
IP  - 6
DP  - 1997 Dec
TI  - Molecular genetics (HLA) of Behcet's disease.
PG  - 333-49
AB  - Behcet's disease (BD) has been known to be strongly associated with the human 
      leukocyte antigen (HLA) B51. This B51 association has been confirmed in many 
      different ethnic groups between the Middle East and Japan, and it has been 
      proposed that BD is prevalent in those ethnic groups along the old Silk Route. 
      The hypothesis could be made that B51 molecules are primarily involved in BD 
      development through specific antigen presentation. However, polymorphic analyses 
      of the TNFB gene and Tau-a microsatellite between the HLA-B and TNF genes 
      indicate that the pathogenic gene of BD is not the HLA-B51 gene itself but 
      another gene located around the HLA-B gene. HLA-C genotyping by the PCR-SSP 
      method also suggests that the BD pathogenic gene is not the HLA-C gene itself but 
      other gene located near the HLA-B gene. Recently we sequenced a single contig of 
      236,822 bp from the MICA gene (58.2 kb centromeric of HLA-B) to 90.8 kb telomeric 
      of HLA-C and identified 8 novel genes designated NOB1-8 (NOB: new organization 
      associated with HLA-B). During the course of the genomic sequence analysis we 
      clarified the genetic structure of the MICA (MHC class I chain-related gene A) 
      gene and found a triplet repeat microsatellite polymorphism of (GCT/AGC)n in the 
      transmebrane (TM) region. Furthermore, the microsatellite allele consisting of 6 
      repetitions of GCT/AGC (MICA A6 allele) was present at a significantly higher 
      frequency in the BD patient group than in the control group and a significant 
      fraction of B51-negative patients were positive for this MICA A6 allele. These 
      results suggest the possibility of a primary association of BD with MICA rather 
      than HLA-B.
FAU - Mizuki, N
AU  - Mizuki N
AD  - Department of Ophthalmology, Yokohama City University School of Medicine, 
      Kanagawa, Japan.
FAU - Inoko, H
AU  - Inoko H
FAU - Ohno, S
AU  - Ohno S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Animals
MH  - Behcet Syndrome/*genetics
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - HLA-B51 Antigen
MH  - HLA-C Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - Microsatellite Repeats
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
RF  - 55
EDAT- 1998/03/24 00:00
MHDA- 1998/03/24 00:01
CRDT- 1998/03/24 00:00
PHST- 1998/03/24 00:00 [pubmed]
PHST- 1998/03/24 00:01 [medline]
PHST- 1998/03/24 00:00 [entrez]
AID - 10.3349/ymj.1997.38.6.333 [doi]
PST - ppublish
SO  - Yonsei Med J. 1997 Dec;38(6):333-49. doi: 10.3349/ymj.1997.38.6.333.