PMID- 9510557
OWN - NLM
STAT- MEDLINE
DCOM- 20001214
LR  - 20190831
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 47
IP  - 5
DP  - 1998 Apr
TI  - Molecular cloning and sequence analysis of interleukin 16 from nonhuman primates 
      and from the mouse.
PG  - 390-7
AB  - Interleukin 16 (IL-16) is synthesized as a 67 000 Mr precursor (pro-IL-16), but 
      only a carboxy terminal part of 12 000-14 000 Mr is secreted by CD8(+) 
      lymphocytes. This lymphokine binds to CD4 and has been shown to induce migration, 
      affect the activation state of T cells, and inhibit immunodeficiency virus 
      replication. It has been suggested that CD8(+) cell-derived soluble factors play 
      a pivotal role in protecting natural-host nonhuman primates from developing 
      immunodeficiency following SIV infection. In a first attempt to address this 
      question, we cloned and sequenced the IL-16 cDNA from different primates. Here we 
      report the pro-IL-16 sequence from chimpanzees, African green monkeys (AGM), 
      rhesus macaques, and cynomolgus macaques. In order to compare and analyze 
      structural motifs possibly involved in processing, intracellular targeting, or 
      secretion, we extended our study to the New World monkeys saimiri and aotus and 
      to the mouse. Alignments of deduced amino acids reveal that the human protein 
      shares 99% similarity to that of chimpanzees, approximately 95% to rhesus, 
      cynomolgus and AGM, about 90% to aotus and saimiri, and 77.5% to the mouse. 
      Phylogenetic analyses revealed the expected evolutionary groupings.
FAU - Bannert, N
AU  - Bannert N
AD  - Paul-Ehrlich-Institut, Paul-Ehrlich-Strasse 51-59, D-63225 Langen, Germany.
FAU - Adler, H S
AU  - Adler HS
FAU - Werner, A
AU  - Werner A
FAU - Baier, M
AU  - Baier M
FAU - Kurth, R
AU  - Kurth R
LA  - eng
SI  - GENBANK/AF007879
SI  - GENBANK/AF017106
SI  - GENBANK/AF017107
SI  - GENBANK/AF017108
SI  - GENBANK/AF017109
SI  - GENBANK/AF017110
SI  - GENBANK/AF017111
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Interleukin-16)
RN  - 0 (Protein Precursors)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - Evolution, Molecular
MH  - Interleukin-16/chemistry/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Primates/*genetics/*immunology
MH  - Protein Precursors/chemistry/genetics
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/analysis/genetics
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
EDAT- 1998/03/25 03:01
MHDA- 2001/02/28 10:01
CRDT- 1998/03/25 03:01
PHST- 1998/03/25 03:01 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 1998/03/25 03:01 [entrez]
AID - 80470390.251 [pii]
AID - 10.1007/s002510050374 [doi]
PST - ppublish
SO  - Immunogenetics. 1998 Apr;47(5):390-7. doi: 10.1007/s002510050374.