PMID- 9512225
OWN - NLM
STAT- MEDLINE
DCOM- 19980429
LR  - 20211203
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 13
IP  - 1
DP  - 1998 Jan
TI  - Human leukocyte antigen matching and fetal loss: results of a 10 year prospective 
      study.
PG  - 33-8
AB  - The role that maternal and fetal human leukocyte antigen (HLA) genes play in 
      pregnancy is unknown, but it has been suggested that fetuses whose HLA alleles do 
      not differ from maternal alleles (i.e. histocompatible fetuses) are more likely 
      to be aborted than fetuses with HLA alleles that differ from maternal alleles 
      (i.e. histoincompatible fetuses). To elucidate the role of HLA compatibility in 
      pregnancy, we tested the hypothesis that couples who match for HLA alleles or 
      haplotypes would have reduced fertility because only these couples could produce 
      histocompatible fetuses. We conducted a 10 year prospective study of HLA matching 
      and pregnancy outcome in 111 Hutterite couples, providing information on 251 
      pregnancies. A logistic regression analysis was performed to determine the 
      effects of HLA matching at HLA regions and loci on pregnancy outcome (fetal loss 
      versus delivery). Significantly increased fetal loss rates were observed among 
      couples matching for the entire 16-locus haplotype (P = 0.002). Among the 
      individual loci, loss rates were increased among couples matching for HLA-B (P = 
      0.019), HLA-C (P = 0.033) and the complement component, C4 (P = 0.043). We 
      interpret these results as evidence that matching for the entire 16-locus 
      haplotype and/or alleles at an HLA-B-linked locus confers significant risk for 
      fetal loss.
FAU - Ober, C
AU  - Ober C
AD  - Center for Medical Genetics and Department of Obstetrics and Gynecology, The 
      University of Chicago, IL 60637, USA.
FAU - Hyslop, T
AU  - Hyslop T
FAU - Elias, S
AU  - Elias S
FAU - Weitkamp, L R
AU  - Weitkamp LR
FAU - Hauck, W W
AU  - Hauck WW
LA  - eng
GR  - R01 HD021244/HD/NICHD NIH HHS/United States
GR  - HD21244/HD/NICHD NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Abortion, Spontaneous/*immunology
MH  - Adult
MH  - Alleles
MH  - Chromosome Mapping
MH  - Ethnicity/*genetics
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Haplotypes
MH  - *Histocompatibility Testing
MH  - Humans
MH  - *Maternal-Fetal Exchange
MH  - Pedigree
MH  - Pregnancy
MH  - Pregnancy, Ectopic/*immunology
MH  - Prospective Studies
MH  - South Dakota
EDAT- 1998/03/25 00:00
MHDA- 1998/03/25 00:01
CRDT- 1998/03/25 00:00
PHST- 1998/03/25 00:00 [pubmed]
PHST- 1998/03/25 00:01 [medline]
PHST- 1998/03/25 00:00 [entrez]
AID - 10.1093/humrep/13.1.33 [doi]
PST - ppublish
SO  - Hum Reprod. 1998 Jan;13(1):33-8. doi: 10.1093/humrep/13.1.33.